摘要
目的 分析临床分离肺炎克雷伯菌的标本类型与临床科室分布情况以及耐药性。方法 采集2021年1月至2022年12月本院患者送检标本中所分离的309株肺炎克雷伯菌进行研究,应用全自动微生物分析仪进行鉴定,采用纸片扩散法进行药敏试验,统计标本来源与科室分布情况,以及肺炎克雷伯菌对不同类型病原菌的耐药性,计算耐药率。结果 309株肺炎克雷伯菌标本主要分离自痰液标本和分泌物标本以及中段尿液标本、血液标本,分别占比53.07%、7.11%、31.71%、4.20%。肺炎克雷伯菌标本在ICU的分布较多,占比25.24%,其次为呼吸内科,占比20.06%,另外,在神经外科的分布也较多,占比8.73%。除此之外,在综合内科、神经内科、泌尿外科的分布也相对较多,占比分别为8.09%、4.53%、4.85%。经耐药性分析,在所分离出的309株肺炎克雷伯菌中,对部分抗菌药物具有较高的耐药性。其中耐药性最高的为氨曲南和氨苄西林/舒巴坦,耐药率均达到33.65%,其次为环丙沙星和左氧氟沙星,耐药率分别达到29.12%和28.80%,另外,对复方新诺明的耐药性也相对较强,耐药率达到27.83%。对阿米卡星与亚胺培南的耐药性则相对较低,耐药率分别为19.41%和20.06%。结论 临床分离的肺炎克雷伯菌主要来自于痰液标本和中段尿液标本、分泌物标本以及血培养标本,相关科室主要涉及到ICU、呼吸内科、神经外科,耐药性较高的抗菌药物主要为氨曲南、氨苄西林/舒巴坦等。
Objective To analyze the specimen type and clinical department distribution of clinical isolates of Klebsiella pneumoniae and drug resistance.Methods A total of 309 strains of Klebsiella pneumoniae isolated from the specimens sent by patients in our hospital from January 2021 to December 2022 were collected for study,identified by fully automatic microbiology analyzer,and tested for drug sensitivity by paper diffusion method,and the distribution of specimens and departments,as well as the resistance of Klebsiella pneumoniae to different types of pathogens were counted to calculate the drug resistance rate.Results The 309 Klebsiella pneumoniae specimens were mainly isolated from sputum specimens and secretion specimens as well as mid-stage urine specimens and blood specimens,accounting for 53.07%,7.11%,31.71%,and 4.20%,respectively.Klebsiella pneumoniae specimens were more distributed in ICU with 25.24%,followed by respiratory medicine with 20.06%,and also in neurosurgery with 8.73%.In addition to this,the distribution in general medicine,neurology,and urology was also relatively high,accounting for 8.09%,4.53%,and 4.85%,respectively.After resistance analysis,among the 309 strains of Klebsiella pneumoniae isolated,they were highly resistant to some antimicrobial drugs.The highest resistance was to amitranam and ampicillin/sulbactam,both with a resistance rate of 33.65%,followed by ciprofloxacin and levofloxacin,with a resistance rate of 29.12%and 28.80%,respectively,and also relatively strong resistance to cotrimoxazole,with a resistance rate of 27.83%.Resistance to amikacin and imipenem was relatively low,with resistance rates of 19.41%and 20.06%,respectively.Conclusions Clinical isolates of Klebsiella pneumoniae were mainly from sputum specimens and mid-stage urine specimens,secretion specimens,and blood culture specimens,and the related departments mainly involved ICU,respiratory medicine,and neurosurgery,and the antimicrobial drugs with high drug resistance were mainly amitrazine and ampicillin/sulbactam.
作者
李磊
高巧珍
LIi Lei;GAO Qiaozhen(Pingtan Comprehensive Experimental Zone Hospital Fuzhou 350400,China)
出处
《中国医药指南》
2024年第10期101-104,共4页
Guide of China Medicine
关键词
肺炎克雷伯菌
标本
分布特点
科室
耐药性
Klebsiella pneumoniae
Specimens
Distribution characteristics
Department
Resistance
