摘要
目的 探讨分析乌鲁木齐市某两家三甲医院分离的肺炎克雷伯菌的临床分布特征及耐药性,指导临床有效使用抗生素。方法 分析2019年1月-12月临床科室患者的血液、尿液、痰液等标本中分离出的肺炎克雷伯菌的耐药情况,采用全自动快速微生物质谱检测系统对分离的肺炎克雷伯菌进行菌种鉴定,采用VITEK-2 Compact全自动微生物分析仪进行药敏试验,WHONET5.6软件导出数据至EXCEL中进行统计学分析。结果 共分离4918株肺炎克雷伯菌,其中男性患者3688人(74.99%),女性患者1230人(25.01%),年龄为28岁-89岁。临床各科室分离的肺炎克雷伯菌中,以重症监护室(ICU)为主(25.86%),其次为呼吸科(9.07%)。标本分布以痰液为主要标本来源(41.03%),其次为尿液(17.73%)和全血(14.29%)。共分离耐药肺炎克雷伯菌为842株。该菌对哌拉西林,呋喃妥因,氨苄西林/舒巴坦的耐药率较高,分别为95.36%、68.90%和57.30%。而对阿米卡星,米诺环素相对较敏感,耐药率为26.01%和27.36%。结论 本市某两家三甲医院分离的肺炎克雷伯菌耐药情况比较严峻,需要继续增强肺炎克雷伯菌的监测,从而更好的降低肺炎克雷伯菌的耐药率,有效阻止肺炎克雷伯菌的传播。
Objective To investigate and analyze the clinical distribution characteristics and drug resistance of Klebsiella pneumoniae isolated in two tertiary hospitals in Urumqi,and to guide the clinical effective use of antibiotics.Methods The drug resistance of Klebsiella pneumoniae strains isolated from clinical departments from January to December 2019 was analyzed,and the types of species were blood,urine,and sputum.Clinical isolates of Klebsiella pneumoniae were identified by automated microbial identification system,drug sensitivity test were used by VITEK-2 Compact automatic microbial analyzer,and data analysis were used for WHONET5.6 software which exported to excel.Results 4918 strains of Klebiella pneumoniae were isolated and detected generally,including 3688 male patients(74.99%)and 1230 female patients(25.01%),and aged 28-89 years.Among the Klebsiella pneumoniae isolated from clinical departments,intensive care unit(ICU)was the main one(25.86%),followed by respiratory department(9.07%).Sputum was the main source of specimen distribution(41.03%),followed by urine(17.73%)and whole blood(14.29%).842 strains of Klebsiella pneumoniae resistant were isolated.The drug resistance rates of the Klebsiella pneumoniae to piperacillin,furantoin and ampicillin/sulbactam were 95.36%,68.90%and 57.30%,respectively.While the drug resistance rate of the Klebsiella pneumoniae to amikacin and minocycline was only 26.01%and 27.36%.Conclusion The drug resistance of Klebsiella pneumoniaeisolated in two tertiary hospitals in Urumqi is serious,Therefore,it is necessary to continue to enhance the monitoring of Klebsiella pneumoniae,in order to reduce the resistance rate of Klebsiella pneumoniae preferably,and prevent the spread of Klebsiella pneumoniae availably.
作者
马晶
冯雪
李娟
沙代提古力·米吉提
徐菲莉
MA Jing;FENG Xue;LI Juan;Shadaitiguli Mijiti;XU Feili(Clinical Center of People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,830001,China;Center for Clinical Laboratory,Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Urumqi,830000,China)
出处
《新疆医学》
2023年第4期418-421,共4页
Xinjiang Medical Journal
基金
新疆维吾尔自治区中医医院院内项目(项目编号:ZYY201616)
关键词
肺炎克雷伯菌
临床分布
耐药性
Klebsiella pneumoniae
Clinical distribution
Drug resistance
