摘要
目的分析急性心力衰竭(acute heart failure,AHF)应用重组人脑利钠肽(recombinant human brain natriuretic peptide,rh-BNP)治疗的效果。方法选取2021年1月~2022年12月蚌埠市中医医院收治的AHF患者97例,按入院顺序编号分组,对照组51例,观察组46例。对照组给予常规治疗,观察组在对照组基础上联合重组人脑利钠肽治疗,对比两组临床疗效、心功能、N末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)及不良反应。结果观察组总有效率95.65%较对照组78.43%更高,差异有统计学意义(χ2=6.179,P<0.05)。治疗后,观察组左心室射血分数(left ventricular ejection fraction,LVEF)水平较对照组更高[(50.99±4.24)%vs.(43.56±4.71)%],左心室舒张末期内径(left ventricular end-diastolic diameter,LVEDD)、左心室收缩末期内径(left ventricular end systolic diameter,LVESD)较对照组更低[(54.15±1.33)mm vs.(58.39±2.12)mm、(35.66±2.65)mm vs.(40.32±2.12)mm],差异有统计学意义(t=8.131、11.650、9.605,P<0.05)。治疗后,观察组NT-proBNP水平较对照组更低[(779.59±59.71)pg ml vs.(1157.59±80.56)pg ml],差异有统计学意义(t=26.019,P<0.05)。观察组不良反应发生率17.39%,稍高于对照组9.80%,但差异无统计学意义(χ2=1.199,P>0.05)。结论AHF应用rh-BNP治疗,有利于改善心功能,促进疗效提高,且不会增加不良反应。
Objective To analyze the therapeutic effect of recombinant human brain natriuretic peptide(rh-BNP)in the treatment of acute heart failure(AHF).Methods 97 cases of AHF patients admitted to Bengbu Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were selected and grouped into 51 cases in control group and 46 cases in study group according to the order of admission.The control group was given conventional treatment,while the research group was treated with recombinant human brain natriuretic peptide in addition to conventional treatment.The clinical efficacy,cardiac function,N-terminal pro-brain natriuretic peptide(NT-proBNP)and adverse reactions of the two groups were compared.Results The total effective rate of the comparison group was 95.65%,higher than that of the control group 78.43%(χ^(2)=6.179,P<0.05).After treatment,the level of left ventricular ejection fraction(LVEF)in the study group was higher than that in the control group,the level of left ventricular end systolic diameter(LVEDD),left ventricular end systolic diameter(LVEDD)in the comparison group was lower than that in the control group(t=8.131,11.650,9.605,P<0.05).The level of NT-proBNP in the study group was lower than that in the control group(t=26.019,P<0.05).The incidence of adverse reactions in the comparison group was 17.39%,higher than 9.80%in the control group,but With no Statistical significance(χ^(2)=1.199,P>0.05).Conclusion The application of rh-BNP in the treatment of AHF is beneficial to improve cardiac function,promote the improvement of curative effect,and does not increase the adverse reaction.
作者
宋文廉
崔颖
肖家军
孙飞
吴刘巨
Song Wenlian;Cui Ying;Xiao Jiajun(Department of Emergency,Bengbu Hospital of Traditional Chinese Medicine,Bengbu 233000,China)
出处
《中华保健医学杂志》
2024年第1期57-59,共3页
Chinese Journal of Health Care and Medicine
基金
安徽省医学会急诊医学会分会2021年急诊临床研究计划项目(Ky2021003)。
关键词
急性心力衰竭
治疗效果
重组人脑利钠肽
心功能
左室射血分数
Acute heart failure
Therapeutic effect
Recombinant human brain natriuretic peptide
Heart function
Left ventricular ejection fraction
