摘要
目的:分析冻干重组人脑利钠肽(rhBNP)联合单硝酸异山梨酯针治疗在急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)术后的应用价值.方法:回顾性分析2020 年6 月至2022 年4 月本院收治的134 例AMI患者的临床资料.按不同药物治疗方法将患者分为联合组(n = 69,采取 rhBNP 联合单硝酸异山梨酯针治疗)与单一组(n = 65,采取rhBNP治疗).比较两组心功能、心肌损伤标志物及炎性因子.结果:治疗后,两组心功能指标左心室射血分数(LVEF)较治疗前增高,左心室舒张末期内径(LVEDd)、左心室收缩末期内径(LVESd)均较治疗前下降,且联合组LVEF明显高于单一组,LVEDd、LVESd低于单一组(P<0.05).治疗后,两组谷草转氨酶(AST)、肌钙蛋白T(cTnT)、肌酸激酶(CK)及肌酸激酶同工酶(CK-MB)水平均较治疗前降低,且联合组上述指标水平均低于单一组(P<0.05).治疗后,两组肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6 及C-反应蛋白(CRP)水平均较治疗前降低,且联合组上述炎性因子水平均低于单一组(P<0.05).结论:rhBNP联合单硝酸异山梨酯针治疗,可有效改善AMI患者PCI术后心功能,减轻炎性反应,降低心肌酶谱水平.
Objective:To analyze the application value of recombinant human brain natriuretic peptide(rhBNP)combined with isosorbide mononitrate acupuncture treatment in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods:The clinical data of 134 patients with AMI admitted to our hospital from June 2020 to April 2022 were retrospectively analyzed.The patients were divided into the combined group(n=69,rhBNP combined with isosorbide mononitrate acupuncture treatment)and the single group(n=65,rhBNP treatment)according to different drug treatment methods.The cardiac function,myocardial injury markers and inflammatory factors were compared between the two groups.Results:After treatment,the cardiac function index left ventricular ejection fractions(LVEF)in the two groups increased compared with before treatment,while left ventricular end diastolic diameter(LVEDd)and left ventricular end systolic diameter(LVESd)were decreased compared with those before treatment,and the LVEF in the combined group was significantly higher than that in the single group,and the LVEDd and LVESd in the combined group were lower than those in the single group(P<0.05).After treatment,the levels of aspartate aminotransferase(AST),cardiac troponin T(cTnT),creatine kinase(CK)and creatine kinase isoenzyme(CK-MB)in the two groups were lower than those before treatment,and the above indexes in the combined group were lower than those in the single group(P<0.05).After treatment,the levels of tumor necrosis factor(TNF)-α,interleukin(IL)-6 and C-reactive protein(CRP)in the two groups were lower than those before treatment,and the levels of the above inflammatory factors in the combined group were lower than those in the single group(P<0.05).Conclusion:rhBNP combined with isosorbide mononitrate acupuncture treatment can effectively improve the cardiac function in patients with AMI after PCI,decrease the inflammatory response,and reduce the level of myocardial enzyme spectrum.
作者
孙海阁
谢鹏飞
SUN Hai-ge;XIE Peng-fei(Department of Cardiology,First People′s Hospital of Pingdingshan,Pingdingshan 467099,China)
出处
《四川解剖学杂志》
2022年第4期57-60,共4页
Sichuan Journal of Anatomy
关键词
急性心肌梗死
冻干重组人脑利钠肽
单硝酸异山梨酯针
Acute myocardial infarction
Freeze-dried recombinant human brain natriuretic peptide
Isosorbide mononitrate injection
