摘要
目前,肝移植被认为是治疗肝细胞癌(HCC)的重要方法之一,但由于肝移植标准严格,对于超出移植标准的患者,肿瘤降期无疑是一种理想的方式,其可以将肿瘤负荷降低到移植标准之内,从而降低肿瘤复发,提高生存时间。目前已有多种治疗方案,如经导管动脉化疗栓塞(TACE)、经动脉放射栓塞(TARE)、肝动脉置管持续化疗灌注(HAIC)、靶向治疗及靶向免疫联合等,被用作HCC降期治疗,但仍存在一些问题限制了HCC肝移植转化治疗的安全性和有效性。本文基于已发表的文献,对目前HCC肝移植转化治疗的现状进行简要阐述。
Liver transplantation is currently considered as one of the most important methods for the treatment of hepatocelluar carcinoma(HCC).However,due to the strict standards of liver transplantation,many patients have exceeded the transplantation standards.For such patients,tumor downstaging is undoubtedly an ideal way,which can reduce the tumor load to the transplantation standards,thereby reducing tumor recurrence and improving survival time.There have been many kinds of descending stage treatment for HCC,such as transcatheter arterial chemoembolization(TACE),transarterial radioembolization(TARE),hepatic arterial infusion chemotherapy(HAIC),targeted therapy alone or in combination with immunotherapy.However,there are still some limits for the safety and effectiveness of liver transplantation conversion therapy for HCC.This article provides a brief introduction of the current status of liver transplantation conversion therapy for HCC based on published literature.
作者
林葳
汤宏涛
何坤
Lin Wei;Tang Hongtao;He Kun(The First Clinical Medical College,Guangdong Medical University,Zhanjiang 524002,China;The First Department of General Surgery(Hepatobiliary Pancreatic Splenic Surgery),Zhongshan City People’s Hospital,Zhongshan 528404,China)
出处
《中华普通外科学文献（电子版）》
CAS
2024年第2期147-150,共4页
Chinese Archives of General Surgery(Electronic Edition)
基金
中山市科技计划项目(2017B1044)。
关键词
癌
肝细胞
肝细胞癌
转化治疗
肝移植
Carcinoma,hepatocellular
Conversion therapy
Liver transplantation
