摘要
随着科学技术的不断发展,亲子鉴定中的嵌合体案例逐渐被发现。亲子鉴定目前通常是在现场采取血样,也有少数机构采取口腔拭子进行STR分型检测。在排除医源性人造异源嵌合体和检材被污染风险因素后,当不同基因座出现多个等位基因异常情况时,往往会考虑被检者为先天嵌合体。但是,如果嵌合体的血液中只存在一种细胞群的时候,血样常染色体STR分型不会出现异常,很容易得出错误的鉴定结论,直接排除亲缘关系。本文所分析案例,就属此类非常罕见的情况。
With the development of technology,more and more cases of chimerism have been found in paternity tests.At present,blood sample is the most commonly used for paternity testing,and a few institutions take oral swabs as samples.After ruling out the possibility of iatrogenic artifi cial chimerism and sample contamination,the presence of multiple alleles in different loci usually indicates congenital chimerism.However,if the chimera blood contains only one type of cell population,the autosomal STR typing of the blood sample will not be abnormal,and it is easy to draw a false identifi cation conclusion that excludes relatives.This paper reports a very rare case of chimera.In this case,gene chimerism was detected only in seminal stain,and no chimerism was found in blood samples,hair and saliva spots.When blood was used for paternity test,the tested father was excluded as the biological father of the two children.However,when sperm plaques were used as samples,it was supported that the tested father was the biological father of the two children.The analysis suggests that the father is a chimera formed by the parthenogenetic division of the mother’s germ cells.Cases of chimerism,which occurs after the fusion of two fertilized eggs,have been reported only in germ cells and not in blood cells.For forensic identifi cation,it is necessary to improve the understanding of chimerism.When the phenomenon of chimerism is suspected,the samples from different parts should be extracted and compared as far as possible.
作者
唐泽英
王璐鑫
陆惠玲
欧奕君
邓小娟
TANG Zeying;WANG Luxin;LU Huiling;OU Yijun;DENG Xiaojuan(Criminal Investigation School,Southwest University of Political Science and Law,Chongqing 401120,China;Forensic Identifi cation Center,Southwest University of Political Science and Law,Chongqing 401120,China;Faculty of Forensic Medicine,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510089,China;Guangdong Tongji Forensic Identifi cation Center,Foshan 528000,Guangdong,China;Hainan Huahai Forensic Material Evidence Judicial Appraisal Institute,Haikou 570125,China)
出处
《刑事技术》
2024年第2期216-220,共5页
Forensic Science and Technology
基金
西南政法大学科研创新基金资助项目(2022-XSZCXY-YJS-007)
关键词
法医遗传学
法医物证
亲子鉴定
嵌合体
forensic genetics
forensic biological evidence
paternity testing
chimera
