摘要
目的探讨慢性胃炎和消化性溃疡患者应用兰索拉唑治疗的疗效和对血清胃肠激素及氧化应激指标的影响。方法选取70例2020年1月至2023年6月余干县中医院收治的慢性胃炎和消化性溃疡患者,按信封随机法分成试验组(35例)、对照组(35例)。对照组施行法莫替丁治疗,试验组在此基础上施行兰索拉唑治疗,对比两组疗效、血清胃肠激素、氧化应激指标、表皮生长因子(EGF)、干扰素-γ(IFN-γ)和转化生长因子-α(TGF-α)指标和不良反应等。结果试验组有效合计率97.14%高于对照组82.86%(P<0.05)。治疗6周后,两组胃泌素-17(GAS-17)与胃蛋白酶原I(PG I)指标升高,胃动素(MTL)指标降低,且试验组GAS-17与PG指标高于对照组,MTL指标低于对照组(P<0.05)。治疗6周后,两组超氧化物歧化酶指标、EGF、TGF-α指标升高,一氧化氮、丙二醛指标、IFN-γ指标下降,且试验组超氧化物歧化酶指标、EGF、TGF-α指标高于对照组,一氧化氮、丙二醛指标、IFN-γ指标低于对照组(P<0.05)。两组肠胃不适、皮肤瘙痒和转氨酶升高等不良反应合计率对比差异无统计学意义(P>0.05)。结论在慢性胃炎和消化性溃疡疾病的治疗中,兰索拉唑的疗效显著,有助于改善人体胃肠激素,调节EGF与TGF-α水平,促进氧化应激状态缓解,且不良反应较少。
Objective Exploring the value of lansoprazole treatment in patients with chronic gastritis(CG)and peptic ulcer(PU),as well as its impact on serum gastrointestinal hormones and oxidative stress index.Methods 70 CG and PU patients admitted to Yugan County Traditional Chinese Medicine Hospital from January 2020 to June 2023 were randomly divided into the experimental group(35 cases)and the control group(35 cases)according to the envelope method.The control group was treated with famotidine,while the experimental group was treated with lansoprazole.The efficacy,serum gastrointestinal hormones,oxidative stress indicators,EGF,IFN-γ and TGF-α indicators,and adverse reactions were compared between the two groups.Results The total effective rate of 97.14% in the experimental group was higher than that of 82.86% in the control group(P<0.05).After 6 weeks of treatment,both groups showed an increase in GAS-17 and this PG I index,while the MTL index decreased.The experimental group had higher GAS-17 and this PG index than the control group,while the MTL index was lower than the control group(P<0.05).After 6 weeks of treatment,the levels of superoxide dismutase,EGF,TGF-α increased,nitric oxide,malondialdehyde,and IFN-γ indicators decreased,in both groups and the experimental group had higher levels of superoxide dismutase,EGF,TGF-α,indicators were lower than those of the control group nitric oxide,malondialdehyde,and IFN-γ than the control group(P<0.05).There was no difference in the total incidence of adverse reactions such as gastrointestinal discomfort,itching,and elevated transaminase levels between the two groups(P>0.05).Conclusion In the treatment of CG and PU diseases,the efficacy of lansoprazole is significant,which helps to improve human gastrointestinal hormones,adjust the levels of EGF and TGF-α,promote the relaxation of oxidative stress states,and there are fewer adverse reactions.
作者
徐斌
XU Bin(Yugan County Traditional Chinese Medicine Hospital,Yugan Jiangxi 335100,China)
出处
《药品评价》
CAS
2023年第12期1553-1556,共4页
Drug Evaluation
关键词
兰索拉唑
消化性溃疡
慢性胃炎
法莫替丁
胃肠激素
Lansoprazole
Peptic ulcer
Chronic gastritis
Famotidine
Gastrointestinal hormones
