摘要
目的探讨含阿莫西林克拉维酸钾四联疗法在幽门螺杆菌(HP)阳性慢性胃炎患者临床治疗中的效果.方法选取该院2021年3月—2023年5月收治的124例HP阳性慢性胃炎患者为研究对象,按照随机数字表法将其分为对照组与观察组,各62例.对照组采用含阿莫西林四联方案治疗,观察组采用含阿莫西林克拉维酸钾四联方案治疗.比较两组患者的胃肠道激素、炎性因子水平、HP转阴率及不良反应发生情况.结果治疗后,观察组的胃泌素(141.33±9.72)ng/L、肿瘤坏死因子-α(14.95±3.27)pg/mL、白细胞介素-6(10.19±2.53)pg/mL、C反应蛋白(7.31±2.02)mg/L均低于对照组的(176.88±10.49)ng/L、(23.55±4.02)pg/mL、(18.77±2.64)pg/mL、(11.44±2.19)mg/L,胃动素(222.08±14.79)ng/L、HP转阴率91.94%均高于对照组的(159.77±13.16)ng/L、67.74%,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论在HP阳性慢性胃炎患者中应用含阿莫西林克拉维酸钾四联疗法效果更佳,能够显著降低机体内炎性因子水平,促进胃肠道激素改善,提高HP转阴率,且安全性高.
Objective To explore the clinical efficacy of amoxicillin potassium clavulanate quadruple therapy in patients with Helicobacter pylori(HP)positive chronic gastritis.Methods 124 patients with HP-positive chronic gastritis admitted to the hospital from March 2021 to May 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 62 cases in each group.The control group was treated with amoxicillin and the observation group was treated with amoxicillin and clavulanate.The levels of gastrointestinal hormones,inflammatory factors,negative HP conversion rate and adverse reactions were compared between the two groups.Results After treatment,the levels of gastrin(141.33±9.72)ng/L,TNF-α(14.95±3.27)pg/mL,interleukin-6(10.19±2.53)pg/mL and C-reactive protein(7.31±2.02)mg/L in the observation group were lower than(176.88±10.49)ng/L,(23.55±4.02)pg/mL,(18.77±2.64)pg/mL,(11.44±2.19)mg/L in the control group,Motilin(222.08±14.79)ng/L and HP negative conversion rate of 91.94%were higher than(159.77±13.16)ng/L and 67.74%of the control group,the differences between groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The use of amoxicillin clavulanate potassium quadruple therapy is more effective in patients with HP positive chronic gastritis.It can significantly reduce the levels of inflammatory factors in the body,promote the improvement of gastrointestinal hormones,increase HP negative conversion rate,and has high safety.
作者
高蕾
GAO Lei(Department of Pharmacy,Jinan Integrated Traditional Chinese and Western Medicine Hospital,Jinan Shandong,271100,China)
出处
《反射疗法与康复医学》
2024年第5期78-80,共3页
Reflexology And Rehabilitation Medicine
关键词
慢性胃炎
幽门螺杆菌阳性
阿莫西林克拉维酸钾
四联疗法
胃肠道激素
不良反应
Chronic gastritis
Positive for Helicobacter pylori
Amoxicillin clavulanate potassium
Quadruple therapy
Gastrointestinal hormones
Adverse reactions
