摘要
目的评估肠道微生态干预对成年非酒精性脂肪性肝病(NAFLD)患者的肝脏特异性、代谢、炎症和肠道微生物群影响的最新证据。方法检索Embase、PubMed、Cochrane Library、Web of Science、中国知网、万方数据库,筛选符合条件的随机临床试验,对纳入研究的数据进行提取和分析。结果纳入37项随机对照试验:20项评估益生菌,2项评估益生元,10项评估合生元,2项评估益生菌和益生元,3项评估益生菌、益生元和合生元,治疗时间7~48周。经网状meta分析,对于大部分临床指标,益生元与合生元组干预效果优于对照组,且呈现出时间相关性,但肠道微生态干预各组干预效果差异无统计学意义。结论网状meta分析表明肠道微生态干预改善了NAFLD的临床指标和肠道微生态,提示合生元可能是一种优于益生菌和益生元的干预措施,但需要足够的剂量和干预时间,我们的研究建议至少连续使用24周。
Objective To assess the latest evidence on the effects of gut microecological intervention on liver-specificity,metabolism,inflammation,and gut microbiota in adult nonalcoholic fatty liver disease(NAFLD)patients.Methods Databases including Embase,PubMed,Cochrane Library,Web of Science,CNKI,and WanFang were searched to collect eligible randomized clinical trials(RCTs),and the data of the included studies were extracted and analyzed.Results A total of 37 RCTs were included,involving 20 probiotics,2 prebiotics,10 synbiotics,2 probiotics and prebiotics,and 3 probiotics,prebiotics and synbiotics,with a treatment duration of 7 to 48 weeks.According to the network meta-analysis,for most clinical indicators,the intervention effects in prebiotics and synbiotics groups were better than those in the control group,and showed a temporal correlation,but there were no statistical differences in the intervention effects among intestinal microecological intervention groups.Conclusion Gut microecology intervention can improve the clinical indicators and gut microecology in NAFLD,although the analyses showed heterogeneity.Network meta-analysis suggests that synbiotics may be a superior intervention to probiotics and prebiotics but requires adequate dosage and intervention time,and our study recommends continuous use for at least 24 weeks.
作者
聂瑞
高洁
陈丹妮
王世令
任茜
NIE Rui;GAO Jie;CHEN Danni;WANG Shiling;REN Qian(The First Clinical Medical College of Lanzhou University,Lanzhou,Gansu 730000,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
北大核心
2024年第2期154-162,167,共10页
Chinese Journal of Microecology
