摘要
目的:探讨肠源性内毒素血症(IETM)在非酒精性脂肪性肝炎(NASH)发生发展中的作用。方法:将12只Wistar大鼠按随机区组设计分为正常对照组和高饱和脂肪酸组(饱和组),观察外周血浆内毒素(LPS)、血清游离脂肪酸(FFA)、肝匀浆肿瘤坏死因子-α(TNF-α)、肝匀浆丙二醛(MDA)含量及肝脂肪变程度。结果:与正常组相比,饱和组血浆LPS、血清FFA、肝匀浆TNF-α及MDA含量均明显升高,且血浆LPS含量与血清FFA、肝匀浆TNF-α及MDA含量分别成正相关。结论:LPS在NAFLD的发生发展中发挥重要作用,促进非酒精性脂肪肝向脂肪性肝炎乃至肝纤维化、肝硬化发展演变。
Objective：To explore the role of intestinal endotoxemia（IETM ）in the occurrence and development of nonalcoholic steatohepatitis （NASH）.Methods：According to random block design, twelve rats were divided into normal control group and high saturated fatty acid group.The rats in two groups were given normal food and high saturated fatty acid food respectively for 9 weeks.Then the levels of plasma endotoxin （LPS）, serum free fatty acid （FFA）,liver homogenate tumor necrosis factor-α （TNF-α ）and malondialdehyde （MDA）in liver homogenate of rats in two groups were measured and pathological changes of liver were observed.Results：Compared with normal control group,the levels of LPS,FFA, TNF-αand MDA were remarkably increased in high saturated fatty acid group,and LPS was correlated positively with the contents of FFA,TNF-α and MDA.Conclusion：IETM plays an important role in the occurrence and development of nonalcoholic steatohepatitis, promotes the development of nonalcoholic fatty liver to NASH, hepatic fibrosis and even hepatic cirrhosis.
出处
《山西中医学院学报》
2008年第2期50-52,共3页
Journal of Shanxi College of Traditional Chinese Medicine
基金
山西省卫生厅科技攻关计划项目(200528)
