摘要
目的 研究新生儿病理性黄疸血清总胆红素、谷草转氨酶(AST)、谷丙转氨酶(ALT)、白蛋白(ALB)水平与蓝光治疗效果的关系。方法 收集2020年6月至2022年12月期间于南阳市中心医院新生儿重症监护病区诊治的97例新生儿病理性黄疸的病历资料,根据患儿蓝光照射治疗效果评估结果分为有效组和无效组,其中有效组共57例,无效组共40例。两组患儿均接受蓝光照射治疗,并进行血清总胆红素、AST、ALT、ALB检测。比较两组治疗前黄疸指数、血清总胆红素、AST、ALT、ALB水平,并分析患儿治疗前血清总胆红素、AST、ALT、ALB水平与蓝光治疗效果相关性。结果 治疗前,有效组黄疸指数低于无效组,差异有统计学意义(t=3.346,P<0.05);有效组血清总胆红素、AST、ALT水平低于无效组,血清ALB水平高于无效组,差异有统计学意义(t=3.635、2.273、2.167、8.689,P<0.05);经Logistic多因素分析,总胆红素、AST、ALT水平变化均为影响新生儿病理性黄疸病情严重程度的独立危险因素,ALB水平变化为影响新生儿病理性黄疸病情严重程度的独立保护因素(P<0.05);经Spearman相关性分析显示,患儿治疗前血清总胆红素、AST、ALT与病情严重程度成正比,ALB水平与病情严重程度成反比(P<0.05)。结论 治疗前新生儿病理性黄疸血清总胆红素、AST、ALT水平越低,ALB越高,可提示患儿病情程度越轻,从而越有利于蓝光治疗效果。
Objective To investigate the relationship between serum total bilirubin,aspartate ami-notransferase(AST),alanine aminotransferase(ALT),albumin(ALB)levels and the efficacy of blue light therapy in newborns with pathological jaundice.Methods The medical records of 97 neonates diagnosed with and treated for pathologic jaundice in the Neonatal Intensive Care Unit of Nanyang Central Hospital from June 2020 to December 2022 were collected retrospectively.The neonates were divided into two groups based on the effectiveness of blue light therapy:an effective group(57 cases)and an ineffective group(40 cases).The jaundice index,serum total bilirubin,AST,ALT and ALB levels were compared between the two groups.The serum levels of bilirubin,AST,ALT and ALB,and their correlation with the effect of blue light therapy were analyzed.Results Before treatment,the icterus index,serum total bilirubin,AST and ALT levels in the effective group were lower than those in the ineffective group,and the serum ALB level was higher than that in the ineffective group(t=3.346,3.635,2.273,2.167,8.689,P<0.05).Through logistic multivariate analysis,it was determined that changes in total bilirubin,AST and ALT levels are independent risk factors that affect the severity of neonatal pathological jaundice.On the other hand,changes in ALB levels were found to be an independent protective factor that affects the severity of pathological jaundice in newborns(P<0.05).Spearman correlation analysis revealed that the levels of serum total bilirubin,AST,and ALT before treatment are directly proportional to the severity of the condition.Conversely,the levels of ALB are inversely propor-tional to the severity of the condition(P<0.05).Conclusion The lower the levels of serum total bilirubin,AST,ALT in neonatal pathological jaundice before treatment,the higher the ALB levels.This suggests that the milder the condition of the chilc,the more beneficial the effect of blue light treatment will be.
作者
王海云
苌俊明
赵杰
朱萍
杨柳
张伟业
薛燕
高航
龚辉
王颖源
WANG Haiyun;CHANG Junming;ZHAO Jie;ZHU Ping;YANG Liu;ZHANG Weiye;XUE Yan;GAO Hang;GONG Hui;WANG Yingyuan(Neonatal Intensive Care Unit of Nanyang Central Hospital,Nanyang,Henan,China,473000;Neonatal Intensive Care Unit of Henan Provincial Children's Hospital,Zhengzhou,Henan,China,450017)
出处
《分子诊断与治疗杂志》
2024年第2期379-382,共4页
Journal of Molecular Diagnostics and Therapy
基金
河南省医学科技攻关计划(LHGJ202106036)。
