摘要
目的探讨血清成纤维细胞生长因子21(FGF21)、分泌型卷曲蛋白5(Sfrp5)、微小RNA-21(miRNA-21)对冠心病(CHD)经皮冠状动脉介入治疗术(PCI)后支架内再狭窄(ISR)的预测价值。方法选择商水县人民医院2021年1月至2022年9月间行PCI手术治疗的CHD患者218例为CHD组,同期非心血管疾病的住院患者97例为对照组,比较两组FGF21、Sfrp5及miRNA-21;CHD组术后随访6个月,以是否发生ISR分为ISR组(n=56)及无ISR组(n=162);分析CHD患者行PCI手术后发生ISR的影响因素,分析FGF21、Sfrp5及miRNA-21对ISR的预测价值。结果CHD组FGF21、miRNA-21均高于对照组,Sfrp5水平低于对照组,差异有统计学意义(t=11.196、15.030、13.685,P<0.05);ISR组低密度脂蛋白胆固醇(LDL-C)、FGF21、miRNA-21均高于无ISR组,Sfrp5水平低于无ISR组,差异有统计学意义(t=7.093、7.216、6.388,P<0.05),ISR组吸烟、合并糖尿病比率高于无ISR组,差异有统计学意义(χ^(2)=6.015、11.295,P<0.05);多因素Logistic回归分析显示,LDL-C、合并糖尿病、FGF21、Sfrp5、miRNA-21是CHD患者行PCI术后发生ISR的影响因素(P<0.05);ROC曲线分析显示,FGF21、Sfrp5、miRNA-21三者单独及联合检测预测PCI术后发生ISR的AUC分别为0.772、0.758、0.763、0.905(P<0.05)。结论血清FGF21、Sfrp5、miRNA-21在行PCI手术后发生ISR的CHD患者中表达异常,联合检测三者水平对于预测CHD患者PCI术后发生ISR具有较好的应用价值。
Objective To investigate the predictive value of serum fibroblast growth factor 21(FGF21),secreted frizzled protein 5(Sfrp5)and microRNA-21(miRNA-21)for in-stent restenosis(ISR)af-ter percutaneous coronary intervention(PCI)in patients with coronary heart disease(CHD).Methods A to-tal of 218 CHD patients who underwent PCI at Shangshui County People's Hospital from January 2021 to Sep-tember 2022 were selected as the CHD group,and 97 hospitalized patients without cardiovascular disease dur-ing the same period were selected as the control group.The levels of FGF21,Sfrp5 and miRNA-21 were com-pared between the two groups.The CHD group was followed up for 6 months after operation,and was divided into the ISR group(n=56)and the non-ISR group(n=162)based on whether ISR occurred or not.The aim was to analyze the influencing factors of ISR after PCI in CHD patients,and to determine the predictive value of FGF21,Sfrp5 and miRNA-21 for ISR.Results FGF21 and miRNA-21 levels were higher in the CHD group compared to the control group,while the level of Sfrp5 was lower than that in the control group(t=11.196,15.030,13.685,P<0.05).Low density lipoprotein cholesterol(LDL-C),FGF21 and miRNA-21 in the ISR group were higher than those in the non-ISR group,and the level of Sfrp5 was lower than that in the non-ISR group,the differences were statistically significant(t=7.093,7.216,6.388,P<0.05).The rates of smoking and diabetes mellitus in the ISR group were higher than those in the non-ISR group,the differences were statistically significant(χ^(2)=6.015,11.295,P<0.05).Multivariate logistic regression analysis showed that LDL-C,diabetes mellitus,FGF21,Sfrp5 and miRNA-21 were the influencing factors for ISR after PCI in CHD patients(P<0.05).The ROC curve analysis showed that the AUC for FGF21,Sfrp5 and miRNA-21 alone and combined de-tection in predicting ISR after PCI were 0.772,0.758,0.763 and 0.905,respectively.Conclusion Serum FGF21,Sfrp5 and miRNA-21 are abnormally expressed in CHD patients with ISR after PCI.The combined de-tectio
作者
彭红建
田香勤
贾国立
PENG Hongjian;TIAN Xiangqin;JIA Guoli(Department of Cardiology,Shangshui People's Hospital,Shangshui,Henan,China,466100;Henan Key Laboratory of Medical Tissue Regeneration,Xinxiang Medical College,Xinxiang,Henan,China,453000;Department of Cardiology,Zhoukou Central Hospital,Zhoukou,Henan,China,466000)
出处
《分子诊断与治疗杂志》
2024年第2期321-325,共5页
Journal of Molecular Diagnostics and Therapy
基金
河南省重点研发与推广专项(232102311072)。
