摘要
转运RNA(tRNA)衍生片段(tRF)又被称为tRNA衍生的小RNA(tsRNAs),是一类新兴的调节性非编码RNA,是在特定条件下特异性切割前tRNA或成熟tRNA而形成的。目前已发现tRF在肿瘤等多种疾病发展进程中具有独特的生物学功能,包括具有miRNA样作用及结合RNA结合蛋白(RBP)调节基因表达、蛋白质翻译、表观遗传学调控、调节细胞周期等。近年来多项研究表明tRF在乳腺癌、胃癌、结直肠癌、肝癌、肺癌、前列腺癌、白血病等多种肿瘤中异常表达并参与其发展进程。本文总结了它们的分类、生物发生、作用机制以及在肿瘤侵袭和转移中的生物意义,为肿瘤的新型诊断标记和治疗靶点的发现提供新思路。
Transfer RNA-derived fragments(tRFs),also known as tRNA-derived small RNAs(tsRNAs),are a class of emerging regulatory non-coding RNAs.They are formed through specific cleavage of pre-tRNA or mature tRNA under certain conditions.TRFs have been found to have various unique biological func-tions in the development of tumors and other diseases.These functions include miRNA-like activities,regulation of gene expression by RNA-binding proteins(RBPs),protein translation,epigenetic regulation,and regulation of the cell cycle.In recent years,multiple studies have shown that tRFs are abnormally expressed and involved in the development of various tumors.These tumors include breast cancer,gastric cancer,colorectal cancer,liver cancer,lung cancer,prostate cancer,and leukemia.This article aims to summarize ther classification,biogene-sis,mechanisms of action,and biological significance of tRFs in tumor invasion and metastasis.By providing new insights,it may contribute to the discovery of novel diagnostic markers and therapeutic targets for tumors.
作者
刘颖军
陈文慧
赵建夫
LIU Yingjun;CHEN Wenhui;ZHAO Jianfu(The First Affiliated Hospital of Jinan University(Guangzhou Overseas Chinese Hospital),Department of Oncology,Guangzhou,Guangdong,China,510632)
出处
《分子诊断与治疗杂志》
2024年第2期199-202,211,共5页
Journal of Molecular Diagnostics and Therapy
基金
广州市科技计划项目资助(202102010083)。
