摘要
tRNA衍生的小RNA(tRNA-derived small RNAs,tsRNAs)是一种来源于成熟tRNA或前体tRNA的非编码小RNA,广泛存在于多种物种中,主要分为tRNA衍生片段(tRNA-derived RNA fragments,tRFs)和tRNA半分子(t RNA halves,tiRNAs)两大类。近年来,随着生物信息学工具及RNA高通量测序技术的快速发展,tsRNAs的生物学功能以及在不同疾病病理生理中的作用被广泛研究,已成为非编码RNA领域的前沿热点。该文就tsRNAs的产生与分类、生物学功能,以及与疾病的关系和其潜在应用进行综述。
tRNA-derived small RNAs(tsRNAs) is a kind of non-coding small RNAs derived from mature tRNA or pre-tRNA, and exists widely in many species. It is mainly divided into two categories: tRNA-derived fragments(tRFs) and tRNA halves(tiRNAs). In recent years, with the rapid development of bioinformatics tools and RNA high-throughput sequencing technology, the biological function of tsRNAs and its role in the pathophysiology of different diseases have been widely studied, which has become a research frontier hotspot in the field of non-coding RNA. This review focuses on the generation and classification of tsRNAs, the biological functions, the relationship with diseases and their potential application.
作者
任峻松
柏文
姚牧笛
赵雅
蒋沁
REN Jun-Song;BAI Wen;YAO Mu-Di;ZHAO Ya;JIANG Qin(The Affiliated Eye Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《生命科学》
CSCD
北大核心
2022年第5期573-580,共8页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(81870679)。
