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激素敏感型肾病综合征儿外周血单个核细胞凋亡的临床研究 被引量:3

Clinical study on the apoptosis of the peripheral blood mononuclear cell in children with steroid-re-sponsive nephrotic syndrome
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摘要 目的 观察肾病综合征(NS)在强的松治疗前后激素敏感者外周血单个核细胞(PBMC)的细胞凋亡变化,以探讨PBMC凋亡在激素治疗中的意义及与尿蛋白的关系。方法37例激素敏感型NS儿分别于强的松治疗前和治疗后第2、4、6、8周采血,进行细胞凋亡形态学观察,计算百分率。结果 治疗前后2、4、6周比较差异均有显著性(P均<0.01);治疗后外周血PBMC与尿蛋白变化呈正相关关系。结论 激素敏感型NS儿使用足量强的松治疗可诱导外周血PBMC细胞凋亡增加,也诱导其病情缓解,当尿蛋白转阴后诱导细胞凋亡随之减少。
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2002年第6期628-629,共2页 Journal of Applied Clinical Pediatrics
基金 广西壮族自治区自然科学基金项目(项目编号:9731011)
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  • 1栾江威,李翠华,熊嗣玉.原发性肾病综合征患儿血尿IL-6和TNF-α含量变化及意义[J].新乡医学院学报,2000,17(6):415-417. 被引量:5
  • 2Boussiotis VA, Lee BJ, Freeman GJ, et al. Induction of T cell clonal anergy results in resistance, whereas CD28 - mediated costimulation primes for susceptibility to Fas - and Bax - mediated programmed cell death[J]. J lmmunol, 1997,159(7) :3156 - 3167. 被引量:1
  • 3Stachowski J, Barth C, Michalkiewicz J, et al. TH1/TH2 balance and CD45 - positive T cell subsets in primary nephrotic syndrome [J]. Pediatr Nephrol,2000,14(8 - 9): 779 - 785. 被引量:1
  • 4Neuhaus TJ, Wadhwa M, Callard R, et al. Increaseed IL-2, IL-4and interferon-gamma in steroid-sensitive nephrotic syndrome[J].Clin Exp Immunol, 1995,100(3) :475 - 479. 被引量:1
  • 5Stevenson FT, Shearer GC, Atkinson DN. Lipoprotein stimulated mesangial cell proliferation and gene expression are regulated by lipoprotein lipase[J]. Kidney Int, 2001, 59(6):2062-2068. 被引量:1
  • 6Sato T, Liang K, Vaziri ND. Down-regulation of lipoprotein lipase and VLDL receptor in rats with focal glomeralosclerosis[J]. Kidney Int, 2002,61(1):157-162. 被引量:1
  • 7Pesce C, Menini S, Pricci F,et al. Glomeralar cell replication and cell loss through apoptosis in experimental diabetes mellitus[J]. Nephronology,2002,90(4):484-488. 被引量:1
  • 8Raij L,Azar S,Keane W. Measangial immune injury, hypertension and progressive glomerular damage in Dahl′s rats[J].Kidney Int,1984,26(2):137-143. 被引量:1
  • 9Wang W, Tzanidis A, Divjak M,et al.Altered signaling and regulatory mechanisms of apoptosis in focal and segmental glomerulosclerosis[J]. J Am Soc Nephrol, 2001,12(7): 1422-1433. 被引量:1
  • 10Park YS, Guijarro C, Kim Y,et al.Lovastatin reduces glomemlar macrophage influx and expression of monocyte chemoattractant protein-1 mRNA in nephritic rats[J]. Am J Kidney Dis, 1998,31(1):190-194. 被引量:1

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