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洛伐他汀对肾硬化大鼠细胞凋亡影响 被引量：2

Influence of lovastatin on cell apoptosis in glomerulosclerosis rats
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摘要 目的　探讨洛伐他汀对高脂血症肾小球硬化大鼠细胞凋亡及凋亡相关蛋白Fas和FasL表达影响。方法　 2 4只Wistar大鼠随机分为对照组、高脂组及洛伐他汀治疗组 ,饲养 12周 ,观察血脂、尿蛋白、肾脏病理积分、肾脏细胞凋亡及Fas和FasL表达。结果　治疗组血胆固醇、三酰甘油、低密度脂蛋白、肾脏病理积分明显低于高脂饮食组 ,肾脏免疫组织化学也显示治疗组细胞凋亡及Fas和FasL表达降低。结论　降脂治疗可降低肾脏细胞凋亡数及Fas和FasL表达 。
作者 樊爱英 韩子明 张贺
机构地区 新乡医学院病理学教研室 新乡医学院第一附属医院儿科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2004年第7期572-574,共3页 Journal of Applied Clinical Pediatrics
关键词 高脂血症 肾小球损伤 降脂治疗 细胞凋亡 大鼠
分类号 R965 [医药卫生—药理学]
  • 相关文献

参考文献10

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二级参考文献15

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共引文献21

同被引文献17

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引证文献2

二级引证文献4

实用儿科临床杂志
2004年 第7期

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