摘要
目的 分析肝硬化并发自发性细菌性腹膜炎(SBP)的危险因素及其与肿瘤坏死因子受体相关因子6(TRAF6)基因多态性的关联。方法 纳入2018年6月-2022年1月桐乡市第一人民医院收治的肝硬化患者153例进行研究,根据其并发SBP情况,分为SBP组52例、非SBP组101例。分析两组TRAF6基因多态性,通过单因素分析及多因素Logistic回归分析法分析肝硬化并发SBP的危险因素。结果 肝硬化患者153例,并发SBP52例,占比为33.99%,SBP组TRAF6基因rs5030445位点AA型占比高于非SBP组(P<0.05)。与非SBP组比较,SBP组年龄>60岁、Child-Pugh分级C级、合并上消化道出血、合并肝性脑病、合并肝肾综合征,血清总胆红素(TBil)水平升高,腹水白蛋白(Alb)水平降低(P<0.05)。多因素Logistic分析结果显示,年龄>60岁、Child-Pugh分级C级、合并肝性脑病、TRAF6基因rs5030445位点AA型为肝硬化并发SBP的危险因素(P<0.05);腹水Alb水平升高为肝硬化并发SBP的保护因素(P <0.05)。结论 肝硬化并发SBP的发生率为33.99%,其发生与TRAF6基因多态性密切相关,肝硬化并发SBP的危险因素较多,可为预防措施的制定提供依据。
OBJECTIVE To explore the risk factors for spontaneous bacterial peritonitis(SBP)in the liver cirrhosis patients and analyze the association with gene polymorphisms of tumor necrosis factor receptor-associated factor 6(TRAF6).METHODS Totally 153 patients with liver cirrhosis who were treated in Tongxiang First People's Hos-pital from Jun 2018 to Jan 2022 were enrolled in the study and were divided into the SBP group with 52 cases and the non-SBP group with 101 cases according to the status of complication with SBP.The TRAF6 gene polymor-phisms were analyzed.Univariate analysis and multivariate logistic regression analysis were performed for the risk factors for the SBP in the liver cirrhosis patients.RESULTS Of the 153 liver cirrhosis patients,52 were complicat-ed with SBP,accounting for 33.99%.The frequency of AA genotype at rs5030445 locus of TRAF6 gene was sig-nificantly higher in the SBP group than in the non-SBP group(P<0.05).The proportions of the patients with more than 60 years of age,grade C of Child-Pugh,complication of upper gastrointestinal hemorrhage,complica-tion of hepatic encephalopathy,complication of hepatorenal syndrome and the serum total bilirubin(TBil)level were significantly higher in the SBP group than in the non-SBP group;while the ascites albumin(Alb)level of the SBP group was significantly lower than that of the non-SBP group(P<0.05).The result of multivariate logistic a-nalysis showed that the more than 60 years of age,grade C of Child-Pugh,complication with hepatic encephalopa-thy and genotype AA at rs5030445 locus of TRAF6 were the risk factos for the SBP in the liver cirrhosis patients(P<0.05);the rise of ascites Alb level was the protective factor for SBP in the liver cirrhosis patients(P<0.05).CONCLUSION The incidence rate of SBP is 33.99%among the liver cirrhosis patients,the incidence is closely as-sociated with the TRAF6 gene polymorphisms.There are a variety of risk factors for the SBP in the liver cirrhosis patients.It can provide bases for formulating prevention measures.
作者
杨三霞
戚昉
吴丽娟
龚文兰
杨佳慧
熊志斌
沈越利
YANG San-xia;QI Fang;WU Li-juan;GONG Wen-lan;YANG Jia-hui;XIONG Zhi-bin;SHEN Yue-li(Tongriang First People's Hospital,Tongriang,Zhejiang 314500,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2024年第5期698-702,共5页
Chinese Journal of Nosocomiology
基金
浙江省医药卫生科技计划基金资助项目(2022ky277)
桐乡市科技局引导基金资助项目(201803099)。
关键词
肝硬化
自发性细菌性腹膜炎
肿瘤坏死因子受体相关因子6
基因多态性
危险因素
关联
Liver cirrhosis
Spontaneous bacterial peritonitis
Tumor necrosis factor receptor-associated factor 6
Gene polymorphism
Risk factor
Association
