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铁调素与活动性肺结核患者强化治疗延长的相关性

Correlation between hepcidin and prolongation of intensive treatment in patients with active pulmonary tuberculosis
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摘要 目的 探讨铁调素与活动性肺结核(APT)患者强化治疗期限的相关性。方法 本研究采用前瞻性队列研究,选择2020年6月至2022年6月期间于联勤保障部队第九二五医院感染科住院或门诊就诊的APT患者297例作为研究对象。所有患者均收集一般资料、实验室资料,实验室检查结果包含铁代谢相关指标。患者开始四联治疗后进行随访,根据患者是否延长强化时限将所有患者分组后比较上述指标之间的差异。采用多因素Logistic回归分析及非限制立方样条(RCS)分析铁代谢相关指标对APT患者强化治疗延长的影响。结果 随访结束时,除脱落23例外,剩余患者分组情况为正常组(n=227)和延长组(n=47)。延长组年龄大于正常组,差异具有统计学意义(P<0.05)。延长组患者铁蛋白及铁调素高于正常组,差异具有统计学意义(P<0.05)。铁调素(OR=1.141,95%CI:1.086~1.203)是影响APT患者强化治疗周期延长的危险因素(P<0.05)。铁调素(非线性=0.106,P<0.001)与APT患者强化周期延长风险呈显著线性关系。结论 铁调素与APT患者强化治疗方案治疗周期延长相关。 Objective To investigate the correlation between hepcidin and duration of intensive treatment in active pulmonary tuberculosis(APT) patients.Methods A prospective cohort study was used in this study.A total of 297 APT patients who were hospitalized or outpatients in the Infection Department of 925th Hospital of Joint Logistics Support Force from June 2020 to June 2022 were selected as the study objects.Their general data and laboratory data were collected for all patients,and the laboratory examination results contained relevant indicators of iron metabolism.They were followed up after initiation of quadruple therapy,and all patients were grouped according to whether the duration of intensification was prolonged or not.Multivariate Logistic regression analysis and unrestricted cubic spline(RCS) were used to analyze the effect of iron metabolism on the extension of intensive treatment in APT patients.Results At the end of follow-up,with the exception of 23 ablations,the remaining patients were divided into the normal group(n=227) and the prolongation group(n=47).The age of the prolongation group was higher than that of the normal group,and the difference was statistically significant(P<0.05).The ferritin and hepcidin in the prolongation group were higher than those in the normal group,and the difference was statistically significant(P<0.05).Hepcidin(OR=1.141,95%CI:1.086~1.203) was a risk factor for prolonged intensive treatment in APT patients(P<0.05).There was a significant linear relationship between hepcidin(nonlinearity=0.106,P<0.001) and the risk of prolonged reinforcement cycle in APT patients.Conclusion Hepcidin is associated with prolonged treatment period of APT patients with intensive chemotherapy regimen.
作者 吕麟亚 刘沛 黄承刚 张俊臣 吴斌军 王建宾 LV Linya;LIU Pei;HUANG Chenggang;ZHANG Junchen;WU Binjun;WANG Jianbin(Department of Infection,the 925th Hospital of Joint Logistic Support Force of PLA,Guiyang,Guizhou 550009,China)
出处 《临床肺科杂志》 2024年第4期582-586,共5页 Journal of Clinical Pulmonary Medicine
基金 贵州省卫生健康委科学技术基金项目(No.gzwkj2023-293)。
关键词 活动性肺结核 铁调素 限制立方样条 active pulmonary tuberculosis hepcidin restricted cubic splines
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