摘要
目的探讨不同剂量甲苯磺酸瑞马唑仑在老年全身麻醉手术患者麻醉诱导中的应用效果。方法选取于湖北理工学院附属黄石爱康医院接受全身麻醉手术的120例老年患者作为研究对象,均采用甲苯磺酸瑞马唑仑进行麻醉诱导,采用随机数字表法分为低剂量组(0.2 mg/kg)、中剂量组(0.3 mg/kg)、高剂量组(0.4 mg/kg),各40例。比较3组患者血流动力学指标[心率(HR)、平均动脉压(MAP)、动脉血氧饱和度(SaO_(2))]、麻醉诱导及苏醒质量、镇静深度[脑电双频指数(BIS)值、改良警觉/镇静评分量表(MOAA/S)评分]及不良反应。结果3组患者麻醉诱导前及气管插管后MAP、SaO_(2)比较,差异无统计学意义(P>0.05);气管插管后,中、高剂量组HR显著低于低剂量组(P<0.05),中剂量组与高剂量组HR比较差异无统计学意义(P>0.05)。中、高剂量组麻醉起效时间显著短于低剂量组(P<0.05),低、中剂量组睁眼时间、拔管时间、PACU停留时间均显著短于高剂量组(P<0.05),低剂量组与中剂量组睁眼时间、拔管时间、PACU停留时间比较差异无统计学意义(P>0.05)。3组麻醉诱导前BIS值、MOAA/S评分差异均无统计学意义(P>0.05);气管插管后,中剂量组、高剂量组BIS值均显著低于低剂量组(P<0.05),MOAA/S评分均显著高于低剂量组(P<0.05),中剂量组与高剂量组BIS值、MOAA/S评分比较,差异无统计学意义(P>0.05)。3组不良反应发生率比较,差异无统计学意义(P>0.05)。结论老年全身麻醉手术患者采用0.3 mg/kg甲苯磺酸瑞马唑仑麻醉诱导,血流动力学指标稳定,麻醉、苏醒质量高,且镇静深度理想。
Objective To explore the effect of different doses of Vamorolone on anesthesia induction in elderly patients undergoing general anesthesia.Methods A total of 120 elderly patients undergoing general anesthesia in Huangshi Aikang Hospital affiliated to Hubei Institute of Technology were selected as the study subjects.All of them were anesthetized with rimazolam toluene sulfonate,and were divided into low-dose group(0.2 mg/kg),medium-dose group(0.3 mg/kg)and high-dose group(0.4 mg/kg)with 40 cases in each group by random number table method.Hemodynamic parameters(heart rate(HR),mean arterial pressure(MAP),arterial oxygen saturation(SaO_2)),quality of anesthesia induction and recovery,depth of sedation(BIS value,modified vigilance/Sedation score(MOAA/S))and adverse reactions were compared among the 3 groups.Results There was no significant difference in MAP and SaO_(2)between 3 groups before anesthesia induction and after tracheal intubation(P>0.05).After endotracheal intubation,HR in medium and high dose groups was significantly lower than that in low dose group(P<0.05),but there was no significant difference in HR between medium dose group and high dose group(P>0.05).The onset time of anesthesia in medium and high dose groups was significantly shorter than that in low dose group(P<0.05),and the eye opening time,extubation time and PACU residence time in low and medium dose groups were significantly shorter than that in high dose group(P<0.05).There was no statistical significance in eye opening time,extubation time and PACU residence time between low dose group and medium dose group(P>0.05).There were no significant differences in BIS and MOAA/S scores among the three groups before anesthesia induction(P>0.05).After endotracheal intubation,BIS value in medium-dose group and high-dose group was significantly lower than that in low-dose group(P<0.05),and MOAA/S score was significantly higher than that in low-dose group(P<0.05).There was no statistical significance in BIS value and MOAA/S score between medium-dose gro
作者
管全胜
刘志军
谭东霞
李永星
蒋松
余良胜
GUAN Quan-Sheng;LIU Zhi-Jun;TAN Dong-Xia;LI Yong-Xing;JIANG Song;YU Liang-Sheng(Department of Anesthesiology,Huangshi Aikang Hospital Affiliated to Hubei Institute of Technology,Huangshi 435000,China;Department of Anesthesiology,Hankou Hospital,Wuhan 430000,China;Department of Anesthesiology,the Fifth Hospital of Huangshi,Huangshi 435005,China)
出处
《中国药物经济学》
2024年第1期55-58,共4页
China Journal of Pharmaceutical Economics
