摘要
目的探讨乌拉地尔和尼卡地平治疗老年高血压急症的疗效和不良反应。方法老年高血压急症患者39例,随机分为乌拉地尔组22例和尼卡地平组17例,分别给予乌拉地尔和尼卡地平降压,记录2组治疗前及治疗后5、10、15、20、25、30、60min、2h及离院时收缩压、舒张压、平均动脉压(MAP)和心率及不良反应。结果 2组治疗前后收缩压、舒张压、MAP和心率比较,差异无统计学意义(P>0.05);2组治疗前后不同时间点收缩压与治疗前收缩压差值比较,差异无统计学意义(P>0.05);2组治疗后2h舒张压和MAP与治疗前差值比较,差异有统计学意义(P<0.05,P<0.01),乌拉地尔组下降更加明显(P<0.01)。结论乌拉地尔和尼卡地平对老年高血压急症症状的缓解及对收缩压降压效果相当;乌拉地尔起效更快且有进一步使舒张压和MAP降低的趋势;2组均可使心率下降,尼卡地平治疗早期患者心率可一过性上升,但并不显著增加心率;2种药物安全性均较好。
Objective To study the efficiency and adverse reactions of urapidil and nicardipine in elderly emergency hypertensive patients. Methods Thirty-nine elderly emergency hypertensive patients were randomly divided into urapidil treatment group （group A,n= 22） and nicardipine treatment group （group B,n=17）. Their SBP,DBP,MAP and adverse reactions were recorded be fore and 5,10,15,20,25,30,60 min,2 h after treatment. Results No significant difference was found in SBP,DBP,MAP and HR between the two groups （P〉0.05） and in SBP between the two groups before and after treatment at different time points （P〉0.05）. The DBP and MAP were significantly lower in group A than in group B 2 h after treatment （P〈0.05 ,P〈0.01 ）. Con- clusion The efficiency of urapidil and nicardipine is similar in alleviating the symptoms and re- ducing the SBP in elderly emergency hypertensive patients. Urapidil can further reduce the DBP and MAP due to its rapider efficiency. Urapidil and nicardipine can decrease the HR. However, nicardipine increases the transient HR but not significantly increases the HR. The safety of urapi dil and nicardipine is good in elderly emergency hypertensive patients.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2014年第4期370-373,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
高血压
急症
肾上腺素能Α拮抗剂
治疗结果
尼卡地平
hypertension
emergencies
adrenergic alpha-antagonists
treatment outcome
nicardip ine
