摘要
目的:观察槐杞黄颗粒联合甲泼尼龙琥珀酸钠对肺炎支原体感染致大叶性肺炎患儿临床症状、炎症反应及免疫功能的影响。方法:选取2020年1月~2022年12月某院收治的150例肺炎支原体感染致大叶性肺炎患儿为研究对象,采用随机数字表法分为对照组和观察组,每组75例。对照组在常规治疗基础上加用甲泼尼龙琥珀酸钠,观察组在对照组治疗基础上加用槐杞黄颗粒。比较两组患儿中医证候积分、炎症因子[高迁移率族蛋白B1(HMGB1)、降钙素原(PCT)、白细胞介素-17(IL-17)、IL-35]、免疫功能指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、临床症状(发热、咳喘、肺部阴影)改善时间以及临床疗效。结果:治疗前,两组中医证候积分比较无统计学差异(P>0.05);治疗后,两组中医证候主症积分、次症积分和总积分均降低,且观察组各项积分均低于对照组(P<0.05)。治疗前,两组HMGB1、PCT、IL-17、IL-35等炎症因子水平比较均无统计学差异(P>0.05);治疗后,两组HMGB1、PCT、IL-17均降低,IL-35均升高(P<0.05),且观察组HMGB1、PCT、IL-17低于对照组,IL-35高于对照组(P<0.05)。治疗前,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)比较无统计学差异(P>0.05);治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均升高,且观察组各指标高于对照组(P<0.05)。观察组退热、咳喘消失、肺部阴影消失时间均短于对照组(P<0.05),且临床治疗总有效率高于对照组(P<0.05)。结论:槐杞黄颗粒联合甲泼尼龙琥珀酸钠可有效减轻肺炎支原体感染致大叶性肺炎患儿的炎症反应,提高免疫功能,加快临床症状的改善和消失。
Objective:To investigate the effects of Huaiqihuang granules combined with methylprednisolone sodium succinate on clinical symptoms,inflammatory factors and immune function of children diagnosed with lobar pneumonia caused by Mycoplasma pneumonia infection.Methods:A total of 150 children with lobar pneumonia caused by Mycoplasma pneumonia infection admitted to our hospital from January 2020 to December 2022 were included in this study.They were randomly divided into a control group and an observation group,with 75 cases in each group.The control group was treated with conventional treatment combined with methylprednisolone sodium succinate,and the observation group was treated with Huaiqihuang granules in addition to conventional treatment combined with methylprednisolone sodium succinate.The study compared the traditional Chinese medicine(TCM)syndrome score,inflammatory factors[high mobility group protein B1(HMGB1),procalcitonin(PCT)and interleukin-17(IL-17),IL-35],immune function[CD3^(+),CD4^(+),CD4^(+)/CD8^(+)],improvement time of clinical symptoms[fever,cough and panting,and lung shadow]and curative effect between the two groups.Results:Before treatment,the scores of TCM symptoms were compared between the two groups,and no statistical significance was found(P>0.05).Both groups showed a decrease in the main symptom score,secondary symptom score and total score of TCM syndromes after treatment(P<0.05).After treatment,the scores of main symptom,secondary symptom and total symptom in observation group were lower than those in control group(P<0.05).Before treatment,there was no statistical significance in inflammatory factors between the two groups(P>0.05).After treatment,HMGB1,PCT and IL-17 decreased,while IL-35 increased(P<0.05).And IL-35 in observation group was higher than that in control group,HMGB1,PCT and IL-17 were lower than that in control group(P<0.05).Before treatment,the immune function of the two groups was compared,and no statistical significance was found(P>0.05).The levels of CD3^(+),CD4^(+),CD4^(
作者
陈小松
于素平
张岩
孙萌萌
韩玉霞
张冰雪
张贵春
宋桂华
CHEN Xiao-song;YU Su-ping;ZHANG Yan;SUN Meng-meng;HAN Yu-xia;ZHANG Bing-xue;ZHANG Gui-chun;SONG Gui-hua(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《中国合理用药探索》
CAS
2024年第2期107-112,共6页
Chinese Journal of Rational Drug Use
关键词
槐杞黄颗粒
甲泼尼龙琥珀酸钠
肺炎支原体感染致大叶性肺炎
炎症反应
免疫功能
Huaiqihuang granules
methylprednisolone sodium succinate
lobar pneumonia caused by Mycoplasma pneumonia infection
inflammatory response
immune function
