摘要
目的 研究克霉唑阴道片(商品名:凯妮汀)治疗妊娠期念珠菌性阴道炎的效果及对患者炎症因子、症状改善时间的影响。方法 选择60例妊娠期念珠菌性阴道炎患者作为研究对象,按随机数字表法分为观察组(30例,采用凯妮汀治疗)与对照组(30例,采用制霉素阴道栓治疗)。比较两组治疗效果、不良反应发生率、症状改善时间及治疗前后阴道菌群培养结果、炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)]水平。结果 观察组临床治疗总有效率96.7%(29/30)显著高于对照组的73.3%(22/30),差异有统计学意义(P<0.05)。观察组不良反应发生率为3.3%(1/30),低于对照组的23.3%(7/30),差异有统计学意义(P<0.05)。观察组症状改善时间为(10.33±2.25)d,对照组症状改善时间为(18.99±3.52)d;观察组症状改善时间显著短于对照组(P<0.05)。治疗后,两组乳酸杆菌活菌计数、肠杆菌活菌计数、酵母菌活菌计数均优于治疗前,且观察组患者的乳酸杆菌活菌计数、肠杆菌活菌计数、酵母菌活菌计数均优于对照组患者,差异有统计学意义(P<0.05);两组治疗后葡萄球菌活菌计数组内及组间比较均无显著性差异(P>0.05)。治疗后,观察组CRP(3.15±0.51)mg/L、IL-6(69.87±4.67)pg/ml、TNF-α(3.41±0.20)μg/L、IL-8(1.99±0.40)pg/ml均低于对照组的(5.30±0.63)mg/L、(81.92±5.05)pg/ml、(4.87±0.38)μg/L、IL-8(3.19±0.51)pg/ml,差异有统计学意义(P<0.05);两组治疗前后CRP、IL-6、TNF-α、IL-8对比存在显著性差异(P<0.05)。结论 妊娠期念珠菌性阴道炎患者通过凯妮汀治疗能够有效提升临床疗效,促进炎症因子改善及症状好转,且安全性更高,值得推广。
Objective To study the effect of clotrimazole vaginal tablets(trade name:Canesten)in the treatment of candida vaginitis during pregnancy and its influence on inflammatory factors and symptom improvement time.Methods 60 pregnant women with candidal vaginitis were selected as the subjects of this study.They were divided into the observation group(30 cases,treated with Canesten)and the control group(30 cases,treated with nystatin vaginal suppository)by numerical table method.Both groups were compared in terms of therapeutic effect,incidence of adverse reactions,time to symptom improvement,results of vaginal bacterial culture before and after treatment,levels of inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8)].Results The total effective rate of clinical treatment in the observation group was 96.7%(29/30),which was significantly higher than 73.3%(22/30)in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 3.3%(1/30),which was lower than 23.3%(7/30)in the control group,and the difference was statistically significant(P<0.05).The symptom improvement time was(10.33±2.25)d in the observation group and(18.99±3.52)d in the control group.The time to symptom improvement of the observation group was significantly shorter than that of the control group(P<0.05).After treatment,the viable count of lactobacillus,enterobacter and yeast in both groups were better than those before treatment;the viable count of lactobacillus,enterobacter and yeast in the observation group were better than those before treatment;the difference was statistically significant(P<0.05).After treatment,there were no significant differences in viable count of staphylococcus within and between the two groups(P>0.05).After treatment,the observation group had CRP of(3.15±0.51)mg/L,IL-6 of(69.87±4.67)pg/ml,TNF-αof(3.41±0.20)μg/L and IL-8 of(1.99±0.40)pg/ml,which were lower than(5.30±0.63)mg/L,(
作者
周雪芳
ZHOU Xue-fang(Xingpu Hospital of Suzhou Industrial Park,Suzhou 215126,China)
出处
《中国现代药物应用》
2024年第5期103-106,共4页
Chinese Journal of Modern Drug Application
关键词
克霉唑阴道片
妊娠
念珠菌性阴道炎
制霉素阴道栓
Clotrimazole vaginal tablets
Pregnancy
Candida vaginitis
Nysfungin vaginal suppositories
