摘要
细胞治疗包括以活细胞为基础的治疗手段和以细胞外囊泡及生物活性分子为主的细胞衍生物治疗方法。细胞治疗作为近年研究热点,是解决难愈创面修复这一临床难题的潜在可行策略。材料科学和细胞生物学的快速发展拉开了细胞治疗的新序幕,同时也提出了如何进一步优化细胞治疗并将其应用于创面修复的新命题。该文回顾了用于创面治疗的细胞类型,汇总了基于细胞治疗新技术的应用和探索,梳理了现有细胞治疗临床应用的困境,并展望了创面修复中细胞治疗的发展趋势,以期促进创新性细胞治疗体系的发展,进一步提高创面临床治疗效果。
Cell therapy includes living cell-based therapy and cell-derivative therapy that is based on extracellular vesicles and bioactive molecules.As a research hotspot in recent years,cell therapy is a potential strategy to solve the clinical problem of refractory wound repair.The rapid development of material science and cell biology has opened a new prelude to cell therapy,and at the same time,puts forward a new proposition on how to further optimize and apply cell therapy to wound repair.This article reviewed the cell types used for wound treatment,summarized the application and exploration of cell therapy-based new technologies,sorted out the difficulties in the clinical application of existing cell therapies,and looked into the future development trend of cell therapy for wound repair,in order to promote the development of innovative cell therapy system and further improve the clinical wound treatment effect.
作者
刘琰
刘欣盈
Liu Yan;Liu Hsinying(Department of Burn,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《中华烧伤与创面修复杂志》
CAS
CSCD
北大核心
2024年第3期221-229,共9页
Chinese Journal of Burns And Wounds
基金
国家自然科学基金面上项目(82072173,82172199,82272262)
上海市生物医药领域定向项目(22DX1900600)
上海市重中之重研究中心项目(2023ZZ02013)
上海市临床重点专科项目(shslczdzk02302)。
关键词
细胞生物学
胞外囊泡
细胞治疗
创面修复
细胞递送
Cell biology
Extracellular vesicles
Cell therapy
Wound repair
Cell delivery
