摘要
目的对毛囊干细胞增殖与分化相关信号通路的研究现状与应用前景进行综述。方法查阅近年国内外关于毛囊干细胞增殖与分化相关信号通路的研究文献,并进行回顾及综合分析。结果调节毛囊干细胞增殖与分化的多条信号通路,包括BMP/TGF-β、Wnt、Notch、外胚层发育不全基因等,在皮肤组织的发育、更新及修复过程中发挥着重要调控作用。结论毛囊干细胞可作为皮肤创面修复的一种重要细胞学治疗方法。
Objective To introduce the basic research and clinical potential of the hair follicle stem cells related signal transduction in proliferation and differentiation.Methods The recent original articles about the hair follicle stem cells were extensively reviewed.Results Many different signal pathways had been involved in the skin development and self-newals.The hair follicle stem cells could play an important role in the skin self-renewal and regeneration which were modulated by several different signal pathways,which included bone morphogenetic protein/transforming growth factorβ,Wnt,Notch and ectodysplasin A genes.Conclusion The hair follicle stem cells may be a future approach to repair cutaneous wounds as a cell therapy.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2010年第2期161-164,共4页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金资助项目(30730090)
国家重点基础研究发展计划(973)资助项目(2005CB522603)~~
关键词
毛囊干细胞
信号转导
细胞增殖
细胞分化
细胞治疗
Hair follicle stem cells Signal transduction Cell proliferation Cell differentiation Cell therapy
