摘要
目的分析慢性心衰急性加重期患者采用重组人脑利钠肽治疗的临床效果。方法随机选取2020年6月—2021年6月临沂市中心医院心内科收治的60例慢性心衰急性加重期患者为研究对象。按照区组随机法分为对照组和研究组,各30例,对照组患者开展常规治疗,研究组患者开展常规治疗+重组人脑利钠肽治疗,分析重组人脑利钠肽的治疗价值。结果治疗后,研究组患者红细胞沉降率、红细胞压积、血浆动力黏度、全血动力黏度、血液血浆动力黏度、QT间期离散度水平、冠状动脉左前降支内径、左室舒张末期内径、左室收缩末期内径水平更低,左室射血分数水平更高,差异有统计学意义(P均<0.05);治疗后,研究组患者血肌酐(77.31±6.43)μmol/L、脑钠肽前体(1328.43±150.96)pg/mL水平更低,表皮生长因子受体(55.31±5.29)mL/(min·1.73 m^(2))水平更高,差异有统计学意义(t=6.243、5.228、6.351,P均<0.05)。结论重组人脑利钠肽治疗在改善患者的心衰相关指标、心功能和血流流变学指标方面表现更为优越,患者治疗后临床效果更好。
Objective To analyze the clinical effect of recombinant human brain natriuretic peptide treatment in pa⁃tients with acute exacerbation of chronic heart failure.Methods 60 patients with acute exacerbation of chronic heart failure admitted to the cardiology Department of Linyi Central Hospital from June 2020 to June 2021 were randomly selected as the study objects.According to the block randomized method,the patients were divided into control group and study group,with 30 cases in each group.The patients in the control group received conventional treatment,and the patients in the study group received conventional treatment plus recombinant human brain natriuretic peptide therapy.The therapeutic value of recombinant human brain natriuretic peptide was analyzed.Results After treatment,erythrocyte sedimentation rate,hematocrit,plasma dynamic viscosity,whole blood dynamic viscosity,blood plasma dy⁃namic viscosity,QT interval dispersion level,left anterior descending coronary artery diameter,left ventricular enddiastolic diameter and left ventricular end-systolic diameter were lower in the study group,and left ventricular ejec⁃tion fraction was higher,the differences were statistically significant(all P<0.05).After treatment,the levels of serum creatinine(77.31±6.43)μmol/L,brain natriuretic peptide precursor(1328.43±150.96)pg/mL were lower in the study group,and the levels of epidermal growth factor receptor(55.31±5.29)mL/(min·1.73 m^(2))were higher,the differences were statistically significant(t=6.243,5.228,6.351,all P<0.05).Conclusion Recombinant human brain natriuretic peptide treatment was more superior in improving patients'heart failure-related indexes,cardiac function and blood flow rheology indexes,and patients had better clinical outcomes after treatment.
作者
周纪星
ZHOU Jixing(Department of Cardiology,Linyi Central Hospital,Linyi,Shandong Province,276000 China)
出处
《中外医疗》
2024年第1期102-105,共4页
China & Foreign Medical Treatment
关键词
慢性心衰急性加重期
重组人脑利钠肽
心功能
Acute exacerbation of chronic heart failure
Recombinant human brain natriuretic peptide
Cardiac
