摘要
目的观察曲安奈德注射液联合开喉剑喷雾剂治疗糜烂型口腔扁平苔藓的临床疗效。方法将100例糜烂型口腔扁平苔藓患者按照随机数字表法分为2组,治疗组50例予曲安奈德注射液联合开喉剑喷雾剂治疗,对照组50例予曲安奈德注射液联合灭菌注射用水治疗。2组均治疗4周,并于治疗2、4周后复诊。比较2组疗效;比较2组治疗前后黏膜愈合评分变化;比较2组治疗前后疼痛视觉模拟评分(VAS)变化;比较2组治疗前后白细胞介素6(IL-6)水平变化;观察2组不良反应。结果2组治疗2周总有效率比较差异无统计学意义(P>0.05);治疗4周治疗组总有效率90.0%(45/50),对照组总有效率66.0%(33/50),治疗组疗效优于对照组(P<0.05)。2组治疗2、4周黏膜愈合评分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组治疗2、4周疼痛VAS均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组治疗4周IL-6水平均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组患者治疗期间均未出现腹泻、恶心、食欲减退、念珠菌性口炎等不良反应。结论曲安奈德注射液联合开喉剑喷雾剂治疗糜烂型口腔扁平苔藓,可有效改善患者口腔黏膜症状,且不良反应较少。
Objective To observe the clinical therapeutic effects of triamcinolone acetonide injection combined with open sword throat spray on erosive oral lichen planus(EOLP).Methods A total of 100 patients with EOLP were divided into 2 groups by a random number table method.The patients received either triamcinolone acetonide injection combined with open sword throat spray for external use(test group,n=50)or triamcinolone acetonide injection combined with normal saline(control group,n=50)for 4 weeks.The curative effectsof the two groups were compared.The changes inmucosal healing(MH)assessment scores,visual analogue scale(VAS)for pain,interleukin-6(IL-6)before and after treatment were assessed between groups.The treatment-emergent adverse events(TEAEs)were observed.Results After 4 week treatment,the total effective rate in test group was superior to the control(90.0%[45/50]vs 66.0%[33/50],P<0.05).The patients in the both groups presented significantly lower MH scores,VAS scores,and IL-6 level(all P<0.05),and the improvements were more pronounced in the test group than those of control group(all P<0.05).No TEAEsoccurredsuch as diarrhea,nausea,loss of appetite and candidal stomatitis in the two groups.Conclusion triamcinolone acetonide injection combined with open sword throat spray in treating EOLP can effectively improve the mucosal symptoms,and it has fewer adverse reaction.
作者
张立立
刘洋洋
刘爱民
ZHANG Lili;LIU Yangyang;LIU Aimin(Department of Stomatology,Tianjin Ninghe Hospital,Tianjin 301509)
出处
《河北中医》
2024年第3期420-423,共4页
Hebei Journal of Traditional Chinese Medicine
关键词
扁平苔癣
口腔
喷雾剂
曲安奈德
Lichen planus,Oral cavity
Spray
Triamcinolone acetonide
