摘要
目的分析加味五子衍宗丸治疗黄体功能不全(LPD)不孕症患者的效果及对雌性激素、妊娠相关蛋白(PAPP-A)、血管内皮生长因子(VEGF)的影响。方法选取2021年11月—2022年12月收治的160例LPD所致肾虚精亏证不孕症。采用随机数字表法分为对照组和研究组,各80例。对照组采用地屈孕酮片治疗,研究组在对照组基础上联用加味五子衍宗丸治疗,均治疗3个月经周期。比较2组临床疗效、妊娠成功率及治疗期间不良反应发生情况。比较治疗前后中医证候积分、血清PAPP-A、VEGF、卵泡素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))和孕酮水平。结果研究组总有效率为93.75%(75/80)高于对照组的82.50%(66/80)(P<0.05)。治疗后,研究组FSH、LH、E_(2)、孕酮、PAPP-A、VEGF水平高于对照组(P<0.05)。随访3个月经周期,研究组妊娠成功率为51.25%(41/80)明显高于对照组的35.00%(28/80)(P<0.05)。2组治疗期间均无药物不良反应发生。结论地屈孕酮片联合加味五子衍宗丸治疗LPD所致肾虚精亏证不孕症获得较好临床效果,调节患者内分泌代谢,提高血清PAPP-A、VEGF水平,提高妊娠成功率。
Objective To analyze the effect of modified Wuzi Yanzong pills in the treatment of patients with infertility due to luteal insufficiency(LPD)and its effects on Estrogen,pregnancy-associated plasma protein A(PAPP-A),and vascular endothelial growth factor(VEGF).Methods A total of 160 infertility patients with kidney deficiency and essence deficiency syndrome caused by LPD were selected from November 2021 to December 2022.They were divided into control group(n=80)and research group(n=80)by random number table method.The control group was treated with Dydrogesterone tablets,and the research group was treated with modified Wuzi Yanzong pills on the basis of the control group,all of which were treated for 3 menstrual cycles.The clinical efficacy,pregnancy success rate and the occurrence of adverse reactions during treatment were compared between the two groups.TCM syndrome score,serum levels of PAPP-A,VEGF,follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2))and progesterone were compared before and after treatment.Results The total effective rate was 93.75%(75/80)in the research group,which was higher than that[82.50%(66/80)]in the control group(P<0.05).After treatment,the levels of FSH,LH,E2,progesterone,PAPP-A and VEGF in the research group were higher than those in the control group(P<0.05).After follow-up of 3 menstrual cycles,the pregnancy success rate of the research group was 51.25%(41/80),which was significantly higher than that of the control group(35.00%,28/80)(P<0.05).No adverse drug reactions occurred in the two groups during treatment.Conclusion In the treatment of infertility patients with kidney deficiency and essence deficiency syndrome caused by LPD,Dydrogesterone tablets combined with modified Wuzi Yanzong pills achieved better clinical efficacy,which regulated endocrine metabolism of patients,increased serum PAPP-A and VEGF levels,and improved pregnancy success rate.
作者
张玮晶
李文香
闫菁强
崔伟
谭世通
李辉
ZHANG Weijing;LI Wenxiang;YAN Jingqiang;CUI Wei;TAN Shitong;LI Hui(department of radiology,the second people's hospital of hengshui city,hengshui,hebei 053800,china;department of reproduction,the second people's hospital of hengshui city,hengshui,hebei 053800,china;department of laboratory,the second people's hospital of hengshui city,hengshui,hebei 053800,china;department of emergency,hengshui hospital of traditional chinese medicine,hengshui,hebei 053000,china)
出处
《转化医学杂志》
2024年第1期21-25,共5页
Translational Medicine Journal
基金
衡水市重点研发计划项目(2021014068Z)。
关键词
加味五子衍宗丸
黄体功能不全
不孕症
妊娠相关血浆蛋白A
血管内皮生长因子
卵泡素
促黄体生成素
雌二醇
Modified Wuzi Yanzong pills
Luteal phase defect
Infertility
Pregnancy-associated plasma protein-A
Vascular endothelial growth factor
Follicle-stimulating hormone
Luteinizing hormone
Estradiol
