摘要
目的探讨活血通络汤在急性缺血性脑卒中(acute ischemic stroke,AIS)患者治疗中的效果及对其对中医证候、神经功能的影响。方法选取82例六安市中医院2021年1月—2022年1月收治的AIS患者作为研究对象,将其分为观察组(41例)和对照组(41例)(随机数字表法)。对照组接受常规西医治疗,观察组在对照组基础上接受活血通络汤治疗。两组治疗时间均为1个月。对两组治疗前后的美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)、蒙特利尔认知评估(Montreal Cognitive Assessment,MoCA)评分、中医证候积分、生活质量评分、全血高切黏度、全血低切黏度、血浆纤维蛋白原(fibrinogen,FIB)及D-二聚体(D-dimer,D-D)水平、血管内皮功能及治疗后的临床疗效进行比较。结果与观察组比较,对照组治疗后临床总有效率较低;治疗后两组中医证候各项评分、NIHSS评分、全血高切黏度、全血低切黏度、血浆FIB、D-D水平、血清内皮素-1(endothelin-1,ET-1)、血管性假血友病因子(von Willebrand factor,vWF)水平与治疗前比均降低,其中观察组低于对照组;治疗后两组生活质量评分、MoCA评分、血清一氧化氮(nitric oxide,NO)、血管舒张功能(flow-mediated dilation,FMD)水平与治疗前比均升高,组间进行比较,对照组较低(P<0.05)。结论活血通络汤应用于AIS患者可有效改善中医证候,利于神经功能和认知功能恢复,提高生活质量,调节血液状态和血管内皮功能,疗效显著。
Objective To investigate the effect of Huoxue Tongluo Decoction(活血通络汤)in the treatment of acute ischemic stroke(AIS)patients and its influence on neurological function and TCM syndrome score.Methods A total of 82 AIS patients admitted to the hospital from January 2021 to January 2022 were selected and divided into an observation group and a control group according to the random number table method,with 41 cases in each.The control group was given conventional western medicine treatment,and the observation group received Huoxue Tongluo Decoction on the basis of the control group.Both groups were treated continuously for 1 month.The clinical efficacy of the two groups after treatment,TCM syndrome scores,whole blood high shear viscosity,National Institute of Health stroke scale(NIHSS),Montreal Cognitive Assessment(MoCA),quality of life score,the levels of whole blood low shear viscosity,plasma fibrinogen(FIB)and D-dimer(D-D)and vascular endothelial function before and after treatment were compared.Results Compared with those of the observation group,the total clinical effective rate of the control group after treatment was lower.After treatment,the scores of TCM syndromes,whole blood low shear viscosity,whole blood high shear viscosity,NIHSS score,the levels of plasma FIB,D-D,serum endothelin-1(ET-1)and von Willebrand factor(vWF)in the two groups were all decreased compared with those before treatment.In comparison,those of the control group were higher.After treatment,the quality of life score,MoCA score,the levels of serum nitric oxide(NO)and flow-mediated dilation(FMD)in the two groups were all higher than those before treatment,and compared with those of the observation group,those of the control group were lower(P<0.05).Conclusion The application of Huoxue Tongluo Decoction in patients with AIS can effectively improve TCM syndromes,facilitate the recovery of neurological function and cognitive function,improve the quality of life,regulate the blood state and vascular endothelial function,and has a sig
作者
鲍婷婷
方无杰
黄友发
周涛
杨言府
BAO Tingting;FANG Wujie;HUANG Youfa;ZHOU Tao;YANG Yanfu(Lu′an Hospital of Traditional Chinese Medicine,Lu′an 237006,Anhui,China)
出处
《辽宁中医杂志》
CAS
北大核心
2024年第3期82-85,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
急性缺血性脑卒中
活血通络汤
神经功能
中医证候
血管内皮功能
acute ischemic stroke
Huoxue Tongluo Decoction(活血通络汤)
neurological function
TCM syndrome
vascular endothelial function
