摘要
目的分析中药注射剂(traditional Chinese medicine injections,TCMIs)致类过敏反应(anaphylatiod reactions,ARs)相关研究文献,了解其研究脉络、热点和发展趋势。方法检索中国知网(CNKI)、维普(VIP)、万方(Wanfang)、Web of Science(WOS)、PubMed数据库中建库至2023年5月1日收录的TCMIs相关ARs的中、英文文献,采用VOSviewer1.6.18绘制核心作者、机构合作及关键词共现网络,运用CiteSpace 5.7.R5进行关键词聚类及突现展示。结果共纳入中文文献190篇,英文文献48篇,文献发文量总体呈波浪式上升又缓慢下降趋势;发表机构以中国中医科学院中药研究所为主,发表文献高达41篇;形成了52位核心作者及梁爱华、易艳等代表性研究团队;研究机构间的合作以中医药大学及附属医院为主;关键词共现与聚类分析显示研究内容侧重于TCMIs相关ARs的作用机制、模型建立、评价方法、检测指标、质量控制;关键词突现分析提示大分子物质、G蛋白偶联受体B2(Mas-related G protein-coupled receptor B2,MRGPRB2)、安全性评价是TCMIs相关ARs未来研究领域的发展趋势。结论TCMIs相关ARs研究热点主要围绕其作用机制、安全性评价展开,体现在TCMIs致ARs成分的筛选、剂量选择及相关通路、受体分析,但此方面研究尚浅,需要借助新的技术手段进行系统挖掘,促进TCMIs相关ARs研究领域的深入发展。
Objective To analyze the research literature related to anaphylatiod reactions(ARs)caused by traditional medicine injections(TCMIs)and to understand the research trends,hot spots and development trends.Methods The Chinese and English literature of TCMIs-related ARs were retrieved from China National Knowledge Internet(CNKI),Vipshop(VIP),Wanfang,Web of Science(WOS),and PubMed databases,built up to May 1,2023,and the core authors,institutional cooperation and keyword cooccurrence network were drawn using VOSviewer 1.6.18 The keyword clustering and emergent display were performed using CiteSpace 5.7.R5.Results A total of 190 articles in Chinese and 48 articles in English were included.The results suggest that the overall number of publications showed a wave-like upward trend and then slowly declined;the publishing institutions were mainly the Institute of Traditional Chinese Medicine,Chinese Academy of Traditional Chinese Medicine,with 41 publications;52 Core authors and representative research teams such as Aihua Liang and Yan Yi were formed;the cooperation between research institutions was mainly in traditional Chinese medicine universities and affiliated hospitals;Keyword co-occurrence and cluster analysis showed that the research content focused on the mechanism of action,modeling,evaluation methods,detection indexes,quality control of TCMIsrelated ARs.The keyword co-occurrence and clustering analysis showed that the research content focused on the mechanism of action,modeling,evaluation methods,detection indexes,and quality control of ARs related to TCMIs;The keyword emergence analysis suggested that macromolecules,Mas-related G protein-coupled receptor B2(MRGPRB2),and safety evaluation represented the future research trends in the field of ARs related to TCMIs.Conclusion At present,the research hotspots of TCMIs-related ARs mainly revolve around their mechanism of action and safety evaluation,which are reflected in the screening,dose selection and analysis of relevant pathways and receptors of TCMIs-causing AR
作者
邓国艳
米惠
刘红宇
欧阳林旗
肖小河
DENG Guoyan;MI Hui;LIU Hongyu;OUYANG Linqi;XIAO Xiaohe(Department of Pharmacy,The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China;School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;PLA Institute of Traditional Chinese Medicine,the Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China)
出处
《中草药》
CAS
CSCD
北大核心
2024年第3期907-918,共12页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金项目(82174069)
湖南省教育厅科学研究项目(21B0375)
湖南省卫健委科研计划课题(C202313057956)
湖南省中医重点专科中药学建设项目(湘中医药函[2023]4号)。
