摘要
目的 探讨大面积脑梗死(LHI)患者血清内脂素(Visfatin)、肌腱蛋白C (TN-C)、白介素-17 (IL-17)水平与神经功能缺损程度的相关性及对患者预后的预测价值。方法 前瞻性选取2020年1月至2023年1月平顶山市第一人民医院收治的80例LHI患者作为LHI组,另选取同期80例非大面积急性脑梗死(ACI)患者作为非LHI组,同期80例健康志愿者作为对照组。比较三组研究对象入院(体检)时的血清Visfatin、TN-C、IL-17水平,并比较LHI组不同神经功能缺损程度患者的血清Visfatin、TN-C、IL-17水平,采用Spearman相关系数分析血清Visfatin、TN-C、IL-17水平与LHI神经功能缺损程度的相关性。比较LHI组不同预后患者入院时血清Visfatin、TN-C、IL-17水平,通过受试者工作特征曲线(ROC)分析血清Visfatin、TN-C、IL-17水平预测预后的价值,采用KM生存曲线分析不同血清Visfatin、TN-C、IL-17水平患者3个月存活情况。结果 LHI组患者入院时的血清Visfatin、TN-C、IL-17水平分别为(86.74±25.17)μg/L、(81.45±20.67)μg/L、(118.19±28.26) pg/mL,明显高于非LHI组的(51.63±16.24)μg/L、(61.29±15.16)μg/L、(76.70±15.49) pg/mL和对照组的(7.71±1.59)μg/L、(19.61±7.38)μg/L、(29.51±6.02) pg/mL,且非LHI组患者的血清Visfatin、TN-C、IL-17水平明显高于对照组,差异均具有统计学意义(P<0.05);LHI组神经功能缺损程度重度患者入院时的血清Visfatin、TN-C、IL-17水平分别为(98.71±18.25)μg/L、(95.38±16.84)μg/L、(135.71±26.03) pg/mL,明显高于中度患者的(79.17±15.61)μg/L、(72.64±14.10)μg/L、(107.11±22.49) pg/mL,差异均具有统计学意义(P<0.05);经Spearman相关分析法分析结果显示,入院时血清Visfatin、TN-C、IL-17水平与LHI患者神经功能缺损程度呈正相关(P<0.05);LHI组预后不良患者入院时的血清Visfatin、TN-C、IL-17水平分别为(101.25±19.17)μg/L、(98.74±17.43)μg/L、(140.71±28.01) pg/mL,明显高于预后良好患者的(78.49±16.20)μg/L、(71.
Objective To investigate the correlation between serum levels of Visfatin,tendinin C(TN-C),and interleukin-17(IL-17) and the degree of neurological impairment in patients with large hemispheric infarction(LHI),and to predict the prognosis of patients.Methods A total of 80 patients with LHI admitted to the Pingdingshan First People's Hospital from January 2020 to January 2023 were prospectively selected as the LHI group,80 patients with non-massive acute cerebral infarction(ACI) were selected as the non-LHI group,and 80 healthy volunteers were selected as the control group.The serum Visfatin,TN-C,and IL-17 levels of the three groups were compared at admission(physical examination),and the serum Visfatin,TN-C,and IL-17 levels of patients with different degrees of neurological impairment in the LHI group were compared.Spearman correlation coefficient was used to analyze the correlation between serum Visfatin,TN-C,IL-17 levels and the degree of LHI neurological impairment.Serum Visfatin,TN-C,and IL-17 levels of patients with different prognosis in the LHI group were compared at admission,and the value of serum Visfatin,TN-C,and IL-17 levels in predicting prognosis was analyzed by receiver operating characteristic curve(ROC).The 3-month survival of patients with different serum Visfatin,TN-C,and IL-17 levels was analyzed by KM survival curve.Results The levels of serum Visfatin,TNC,and IL-17 in LHI group were(86.74±25.17) μg/L,(81.45±20.67) μg/L,and(118.19±28.26) pg/mL,respectively,significantly higher than(51.63±16.24) μg/L,(61.29±15.16) μg/L,(76.70±15.49) pg/mL in the non-LHI group and(7.71±1.59) μg/L,(19.61±7.38) μg/L,(29.51±6.02) pg/mL in the control group(P<0.05);the levels of serum Visfatin,TN-C,and IL-17 in non-LHI group were significantly higher than those in control group(P<0.05).Serum Visfatin,TNC,and IL-17 levels of patients with severe neurological impairment in the LHI group were(98.71±18.25) μg/L,(95.38±16.84) μg/L,and(135.71±26.03) pg/mL,respectively,significantly higher than(79.17±
作者
李小磊
李华丽
石伟纲
LI Xiao-lei;LI Hua-li;SHI Wei-gang(Neurological Intensive Care Unit,Pingdingshan First People's Hospital,Pingdingshan 467099,Henan,CHINA)
出处
《海南医学》
CAS
2024年第5期614-619,共6页
Hainan Medical Journal
基金
2021年度河南省医学科技攻关计划联合共建项目(编号:LHGJ20211219)。
