摘要
目的探究结直肠患者术后及时给予早期肠内营养支持的临床效果。方法82例行结直肠癌手术的结直肠癌患者,依据随机数字表法分为观察组和对照组,每组41例。两组均在术后给予营养支持,对照组行肠外营养支持,观察组行早期肠内营养支持。对比两组的临床相关指标、营养状态指标、胃肠功能指标[生长抑素(SS)、血管活性肠肽(VIP)、胃泌素(GAS)、胃动素(MTL)]、炎性因子[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]及并发症发生率。结果观察组肛门首次排气时间(43.95±5.26)h、首次下床时间(40.37±7.92)h、住院天数(12.27±3.65)d均短于对照组的(58.87±6.94)h、(55.65±8.36)h、(14.86±4.06)d(P<0.05)。干预后,观察组前白蛋白、白蛋白、转铁蛋白水平分别为(267.47±19.94)mg/L、(39.18±4.95)g/L、(2.07±0.25)g/L,高于对照组的(244.23±18.58)mg/L、(35.47±3.45)g/L、(1.87±0.21)g/L(P<0.05)。干预后,观察组SS(47.87±4.54)ng/L低于对照组的(52.56±3.86)ng/L,GAS(118.34±15.74)ng/L、VIP(34.12±6.85)ng/L与MTL(66.31±10.22)ng/L高于对照组的(86.57±11.48)、(27.84±8.11)、(53.76±11.14)ng/L(P<0.05)。干预后,观察组TNF-α、IL-6与CRP水平分别为(182.38±14.43)ng/L、(254.28±33.76)ng/L、(9.32±1.85)mg/L,低于对照组的(238.94±25.51)ng/L、(336.57±34.52)ng/L、(11.89±2.68)mg/L(P<0.05)。观察组并发症发生率4.88%低于对照组的19.51%(χ^(2)=4.100,P=0.043<0.05)。结论针对结直肠癌患者,对其术后及时行早期肠内营养支持,可促进患者康复加速,改善营养状态、胃肠功能,同时有利于减轻炎症反应,控制并发症发生,价值突出。
Objective To explore the clinical effect of early postoperative enteral nutrition support in patients with colorectal cancer.Methods A total of 82 patients with colorectal cancer who underwent colorectal cancer surgery were divided into the observation group and the control group according to the random number table method,with 41 cases in each group.Both groups received postoperative nutritional support,with the control group receiving parenteral nutrition support and the observation group receiving early enteral nutrition support.Comparison was made on clinical related indicators,nutritional status indicators,gastrointestinal function indicators[somatostatin(SS),vasoactive intestinal peptide(VIP),gastrin(GAS),motilin(MTL)],inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)],and incidence of complications between the two groups.Results In the observation group,the first anal exhaust time was(43.95±5.26)h,the first ambulation time was(40.37±7.92)h,and the length of hospital stay was(12.27±3.65)d,which were shorter than(58.87±6.94)h,(55.65±8.36)h,and(14.86±4.06)d in the control group(P<0.05).After intervention,the levels of prealbumin,albumin and transferrin in the observation group were(267.47±19.94)mg/L,(39.18±4.95)g/L and(2.07±0.25)g/L,which were higher than(244.23±18.58)mg/L,(35.47±3.45)g/L and(1.87±0.21)g/L in the control group(P<0.05).After intervention,SS of(47.87±4.54)ng/L in the observation group作was lower than(52.56±3.86)ng/L in the control group;the observation group had GAS of(118.34±15.74)ng/L,VIP of(34.12±6.85)ng/L and MTL of(66.31±10.22)ng/L,which were higher than(86.57±11.48),(27.84±8.11)and(53.76±11.14)ng/L in the control group(P<0.05).After intervention,the levels of TNF-α,IL-6 and CRP in the observation group were(182.38±14.43)ng/L,(254.28±33.76)ng/L and(9.32±1.85)mg/L,which were lower than(238.94±25.51)ng/L,(336.57±34.52)ng/L and(11.89±2.68)mg/L in the control group(P<0.05).The complication rate of 4.88%in the observati
作者
周楠
ZHOU Nan(Department of Nutrition,General Hospital of the Northern Theater Command,Shenyang 110011,China)
出处
《中国现代药物应用》
2024年第4期160-163,共4页
Chinese Journal of Modern Drug Application
关键词
结直肠癌
早期肠内营养支持
营养状况
胃肠功能
炎性因子
Colorectal cancer
Early postoperative enteral nutrition support
Nutritional status
Gastrointestinal function
Inflammatory factors
