摘要
缺血性脑卒中(ischemic stroke,IS)是成人致死和致残的主要疾病,严重损害居民健康。IS发病机制复杂,目前临床治疗方法有限。因此,阐明其病理机制对于探索IS预防和治疗新策略具有重要意义。炎症反应在IS的病理过程中扮演不可或缺的角色,在脑缺血后继发性损伤的机制中起关键作用,加快了缺血性损伤的形成并影响神经元死亡和神经组织再生过程。在IS的急性期,小胶质细胞激活和外周免疫细胞浸润是炎症反应的主要特点。趋化素样因子1(chemokine-like factor 1,CKLF1)是一种非经典的具有趋化活性的因子,在成熟大脑中几乎检测不到,但在IS后能被重新激活和表达。CKLF1在IS的炎症反应过程中扮演复杂的角色。研究CKLF1在IS炎症反应中的作用对进一步探寻脑卒中的治疗方法具有重要意义。
Ischemic stroke(IS)is a major cause of death and disability in adults,seriously compromising public health.The pathogenesis of IS is complex,and current clinical treatment methods are limited.Therefore,elucidating its pathological mechanisms is of great significance for exploring new strategies for the prevention and treatment of IS.The inflammatory response plays an indispensable role in the pathological process of IS,playing a key role in the mechanism of secondary damage after cerebral ischemia,accelerating the formation of ischemic damage,and affecting the process of neuron death and nerve tissue regeneration.In the acute phase of IS,microglial activation and peripheral immune cell infiltration are the main features of the inflammatory response.Chemokinelike factor 1(CKLF1)is a non-classical factor with chemotactic activity and is barely detectable in the mature brain but can be reactivated and expressed after IS.CKLF1 plays a complex role in the inflammatory response process of IS.Studying the role of CKLF1 in IS inflammatory response is of great significance for further exploring the treatment methods for stroke.
作者
武会敏
葛朝明
WU Huimin;GE Zhaoming(Department of Neurology,Second Hospital of Lanzhou University,Lanzhou 730030;Second Clinical Medical School of Lanzhou University,Lanzhou 730030,China)
出处
《临床与病理杂志》
CAS
2023年第12期2171-2175,共5页
Journal of Clinical and Pathological Research
基金
甘肃省科技计划项目(20JR10FA663)。
关键词
缺血性脑卒中
趋化素样因子1
炎症反应
ischemic stroke
chemokine-like factor 1
inflammatory response
