摘要
目的:观察加减复元活血汤治疗气滞血瘀型骨质疏松性腰椎压缩骨折(OLCF)患者的临床疗效。方法:选择2020年1月至2021年12月河北省张家口市第二医院中医骨伤科气滞血瘀型OLCF住院患者71例,均初次行经皮椎体成形术(PVP),采用随机数字表法分为两组,对照组(n=35)在术后常规使用抗骨质疏松药(钙尔奇D+罗盖全),研究组(n=36)在对照组基础上加用加减复元活血汤。比较两组的腰椎功能、疼痛程度、骨强度、中医证候积分及临床疗效。结果:JOA的时间变化与组别之间具有交互作用(P<0.05);组间比较:治疗8周、12周两组的JOA组间比较,差异有统计学意义(P<0.05);时间比较:治疗8周、12周两组的JOA均大于治疗前(P<0.05)。ODI、VAS评分、活动受限积分、椎体僵硬积分、腰体疼痛积分的时间变化与组别之间具有交互作用(P<0.05);组间比较:治疗8周、12周两组的ODI、VAS评分、活动受限积分、椎体僵硬积分、腰体疼痛积分组间比较,差异有统计学意义(P<0.05);时间比较:治疗8周、12周两组的ODI、VAS评分、活动受限积分、椎体僵硬积分、腰体疼痛积分均小于治疗前(P<0.05)。骨密度、骨矿含量、ALP、BGP、PINP、CTXI的时间变化与组别之间具有交互作用(P<0.05);组间比较:治疗8周、12周两组的骨密度、骨矿含量、ALP、BGP、PINP、CTXI组间比较,差异有统计学意义(P<0.05);时间比较:治疗12周,对照组的骨密度、骨矿含量、BGP较治疗前升高(P<0.05),ALP、PINP、CTXI较治疗前降低(P<0.05),治疗8、12周,研究组骨密度、骨矿含量、BGP较本组治疗前升高(P<0.05),ALP、PINP、CTXI较治疗前降低(P<0.05)。研究组总有效率93.94%(31/33)对照组总有效率75.76%(25/33),两组总有效率比较差异有统计学意义(P<0.05),研究组疗效优于对照组。结论:加减复元活血汤可改善气滞血瘀型OLCF患者腰椎功能与骨强度,调节骨代谢,减轻疼痛、临床症状等不适,效果
Objective:to analyze the effect of modified Fuyuan Huoxue Decoction on patients with osteoporotic lumbar compression fracture(OLCF)of qi stagnation and blood stasis type.Methods:71 patients with olcf of qi stagnation and blood stasis type who were hospitalized in our hospital from January 2020 to December 2021 and met the inclusion criteria were selected to undergo percutaneous vertebroplasty(PVP)for the first time.The selected patients were divided into two groups by random number table method.The control group(n=35)routinely used anti osteoporotic drugs(Caltech D+luogaiquan)after operation,and the study group(n=36)added modified Fuyuan Huoxue Decoction on the basis of the control group.The lumbar function,pain degree,bone strength,TCM syndrome score and curative effect of the two groups werecompared.Results:There is an interaction between the temporal changes of JOA and the groups(P<0.05);Inter group comparison:There was a statistically Significant difference(P<0.05)between the JOA groups after 8 and 12 weeks of treatment;Time comparison:The JOA of the two groups at 8 and 12 weeks of treatment were higher than before treatment(P<0.05).There was an interaction between the time changes of ODI,VAS score,activity limited score,vertebral stiffness score,and lumbar pain score and the groups(P<0.05);Inter group comparison:There was a statistically significant difference in ODI,VAS score,limited mobility score,vertebral stiffness score,and lumbar pain score between the two groups after 8 and 12 weeks of treatment(P<0.05);Time comparison:The ODI,VAS score,limited activity score,vertebral stiffness score,and lumbar pain score of the two groups after 8 and 12 weeks of treatment were all lower than before treatment(P<0.05).The temporal changes of bone density,bone mineral content,ALP,BGP,PINP,and CTXI had an interaction with the groups(P<0.05);Comparison between groups:There was a statistically significant difference in bone density,bone mineral content,ALP,BGP,PINP,and CTXI between the two groups after 8 and 12 weeks of t
作者
张岩
魏星
安海库
黄姝变
张慧园
王利锋
ZHANG Yan;WEI Xing;AN Haiku(Department of orthopedics and traumatology of traditional Chinese medicine,Zhangjiakou second hospital,Zhangjiakou Hebei 075000,China)
出处
《四川中医》
2023年第12期172-176,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
张家口市重点研发计划项目(编号:2021110D)。
关键词
复元活血汤
骨质疏松性腰椎压缩骨折
腰椎功能
疼痛程度
Fuyuan Huoxue Decoction
Osteoporotic lumbar compression fracture
Lumbar function
Degree of pain
