摘要
目的:探讨D-二聚体、凝血酶原时间(PT)、纤维蛋白(原)降解产物(FDP)、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)这五项凝血指标水平与肾病综合征的关联和临床应用价值。方法:对138例肾病综合征患者,130例肾小球肾炎患者和136例健康者的凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原、D-二聚体和纤维蛋白(原)降解产物进行检测,并进行比较。结果:肾病综合征患者组的FDP、FIB和D-二聚体检测高于肾小球肾炎组和健康对照组(P<0.05);肾病综合征组的D-二聚体、FDP阳性率分别为86.8%和68.4%高于肾小球肾炎组和健康对照组(P<0.05);肾病综合征组的PT和APTT结果低于肾小球肾炎组和健康对照组,两组比较差异无统计学意义(P>0.05);肾小球肾炎组D-二聚体、FDP、FIB、PT和APTT与健康对照组比较差异无统计学意义(P>0.05)。结论:D-二聚体、纤维蛋白(原)降解产物和纤维蛋白原的水平可以提示肾病综合征患者的血凝状态和血栓风险,有利于患者的合理诊疗及血栓预防。
Obsjective:To investigate the relationship between the levels of D-dimer,prothrombin time(PT),fibrin(-ogen) degradation products(FDP),fibrinogen(FIB),activated partial thromboplastin time(APTT) and nephrotic syndrome and their clinical application value. Methods:The PT,APTT,FIB,D-dimer and FDP of 138 patients with nephrotic syndrome,130 patients with glomerulonephritis and 136 healthy people were detected and compared. Results:The results of D-dimer,FDP and FIB of nephrotic syndrome group were significantly higher than those of glomerulonephritis group and healthy control group(P< 0.05). The positive rates of D-dimer and FDP in nephrotic syndrome group were 86.8% and 68.4% respectively,which were higher than those in glomerulonephritis group and healthy control group(P<0.05). The results of PT and APTT in nephrotic syndrome group were lower than those in glomerulonephritis group and healthy control group with no statistical difference(P>0.05). There was no statistical difference in D-dimer,FDP,FIB,PT and APTT between glomerulonephritis group and healthy control group(P>0.05). Conclusion:The levels of D-dimer,FDP and FIB can indicate the coagulation status and thrombus risk of patients with nephrotic syndrome,which is beneficial to the reasonable diagnosis and treatment of patients and thrombus prevention.
作者
刘海波
卢佩
李春梦
朱兵兵
白妮
LIU Haibo;LU Pei;LI Chunmeng(Shaanxi Traditional Chinese Medicine Hospital,Xi’an 710003)
出处
《陕西医学杂志》
CAS
2020年第4期506-509,共4页
Shaanxi Medical Journal
基金
西安市科技局项目[201805103YX11SF37(15)]。
