摘要
目的分析不同肾损害期糖尿病患者进行胱抑素与糖化血红蛋白联合测定的重要性。方法选择和平县人民医院2017年6月-2020年6月收治的80例糖尿病患者作为研究对象,根据患者尿白蛋白水平将患者分为正常组(26例)、微量组(26例)和大量组(28例),与此同时,选取同期健康体检的健康者30名作为对照组,对比不同组别患者血清胱抑素(Cystatin C)与糖化血红蛋白水平(HbA1c)。结果尿蛋白水平正常组患者血清胱抑素C(0.73±0.46)mg/L与糖化血红蛋白水平(5.15±0.32)%与对照组血清胱抑素(0.65±0.11)mg/L与糖化血红蛋白水平(5.05±0.28)%比较,差异无统计学意义(P>0.05)。与对照组相比,血清胱抑素C水平;微量组(2.22±0.89)mg/L、大量组(5.67±1.29)mg/L升高,糖化血红蛋白水平:微量组(7.35±1.20)%、大量组(9.64±2.05)%均有所升高,差异有统计学意义(P<0.05)。结论不同肾损害期糖尿病患者进行胱抑素与糖化血红蛋白联合测定具有较高的临床价值,胱抑素与糖化血红蛋白水平会随着糖尿病患者肾损害期的进展而逐渐升高,可以准确判断糖尿病患者的肾损害程度。
Objective To analyze the importance of combined determination of cystatin and glycosylated hemoglobin in diabetic patients with different renal impairment.Methods The 80 patients with diabetes who were admitted to Heping county people’s hospital from June 2017 to June 2020 were selected as the research objects.According to the urine albumin level of the patients,the patients were divided into normal group(26 cases),micro-group(26 cases)and large group(28 cases).At the same time,30 healthy people who received physical examinations during the same period served as the control group to compare the serum cystatin(Cystatin C)and glycosylated hemoglobin levels(HbA1c)of patients in different groups.Results The serum cystatin C(0.73±0.46)mg/L and glycosylated hemoglobin levels(5.15±0.32)%of patients with normal urine protein levels were compared with the control group's serum cystatin C(0.65±0.11)mg/L and glycosylated hemoglobin levels(5.05±0.28)%,the difference was not statistically significant(P>0.05).Compared with the control group,serum cystatin C level trace group(2.22±0.89)mg/L,large group(5.67±1.29)mg/L increased,glycated hemoglobin level trace group(7.35±1.20)%,large group(9.64±2.05)%increased,and the difference was statistical significance(P<0.05).Conclusion The combined determination of cystatin and glycosylated hemoglobin in diabetic patients with different renal impairment stages has a high clinical value.The levels of cystatin and glycosylated hemoglobin will gradually increase with the progression of the renal impairment in diabetic patients,which can accurately judge diabetes.
作者
黄伟平
谢仟卫
HUANG Weiping;XIE Qianwei(Heping County People's Hospital,Heyuan,Guangdong Province,517200 China)
出处
《糖尿病新世界》
2021年第7期62-65,共4页
Diabetes New World Magazine
关键词
糖尿病
肾损害
血清胱抑素C
糖化血红蛋白
重要性
临床诊断
Diabetes
Renal damage
Serum cystatin C
Glycosylated hemoglobin
Importance
Clinical diagnosis
