摘要
目的探讨湿化高流量鼻导管通气(HHFNC)联合枸橼酸咖啡因治疗早产儿呼吸暂停反复发作的效果。方法抽取2019年10月至2021年8月平煤神马医疗集团总医院收治的呼吸暂停反复发作的早产儿70例,按照随机数字表法分为对照组与观察组,每组35例。对照组采用经鼻持续气道正压通气联合枸橼酸咖啡因治疗,观察组采用HHFNC联合枸橼酸咖啡因治疗。对比两组疗效、症状改善情况(呼吸暂停消失时间、治疗48 h内呼吸暂停次数、用氧时间、通气时间)、治疗前后血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]及并发症发生率。结果观察组总有效率(94.29%,33/35)高于对照组(71.43%,25/35),P<0.05;观察组呼吸暂停消失时间、治疗48 h内呼吸暂停次数、用氧时间、通气时间短于对照组(P<0.05);治疗24 h后,观察组PaO_(2)水平高于对照组,PaCO_(2)水平低于对照组(P<0.05)。观察组并发症发生率(8.57%,3/35)低于对照组(28.57%,10/35),P<0.05。结论HHFNC联合枸橼酸咖啡因治疗早产儿呼吸暂停反复发作疗效较好,能有效缓解呼吸暂停症状,缩短通气时间,改善患儿血气指标,且治疗安全性较高。
Objective To investigate the effect of humidified high-flow nasal catheter ventilation(HHFNC)combined with caffeine citrate on recurrent apnea in premature infants.Methods A total of 70 premature infants with recurrent apnea treated in Pingmei Shenma Medical Group General Hospital from October 2019 to August 2021 were selected,and they were divided into control group and observation group according to random number table method,with 35 cases in each group.The control group received nasal congestion type continuous positive airway pressure combined with caffeine citrate,and the observation group received HHFNC combined with caffeine citrate.The efficacy,symptom improvement(disappearance time of apnea,number of apneas within 48 hours of treatment,oxygen use time,ventilation time),blood gas indexes,including arterial partial pressure of oxygen(PaO_(2))and partial pressure of carbon dioxide in arterial blood(PaCO_(2))before and after treatment and incidence of complication of the two groups were compared.Results The total effective rate of the observation group was 94.29%(33/35),higher than that of the control group(71.43%,25/35),P<0.05.Compared with the control group,the disappearance time of apnea within 48 hours of treatment,number of apneas,oxygen time and ventilation time of the catheter group were shorter(P<0.05).Compared with the control group,the observation group had higher PaO_(2) level and lower PaCO_(2) level after 24 hours of treatment(P<0.05).The incidence of complication of the observation group(8.57%,3/35)was lower than that of the control group(28.57%,10/35),P<0.05.Conclusions HHFNC combined with caffeine citrate has good efficacy in the treatment of recurrent apnea in premature infants,which can effectively relieve symptoms of apnea,shorten ventilation time,improve blood gas indexes in children,with high safety.
作者
杜亚丽
Du Yali(Department of Pediatrics,Pingmei Shenma Medical Group General Hospital,Pingdingshan 467000,China)
出处
《中国实用医刊》
2023年第22期69-72,共4页
Chinese Journal of Practical Medicine
关键词
呼吸暂停
早产儿
湿化高流量鼻导管通气
枸橼酸咖啡因
Apnea
Premature infant
Humidified high-flow nasal catheter ventilation
Caffeine citrate
