摘要
目的:分析尼达尼布不良反应的发生规律与特点,为临床合理用药提供参考。方法:检索建库至2022年10月中国知网、维普数据库、万方数据库、Web of Science数据库与PubMed数据库中有关尼达尼布不良反应的文献并进行统计分析。结果:尼达尼布相关不良反应案例报道共19篇,涉及21例患者,其中年龄分布以60岁以上老年人较多(17例,80.95%),不良反应多发生在用药后30 d内(8例,38.10%),不良反应累及的系统-器官以胃肠道疾病占比最高(6例,28.57%)。3例停药后好转,9例停药并接受对症治疗后好转,4例停药并接受手术治疗后好转,4例未停药并接受对症治疗后好转,1例未停药并接受手术治疗后好转。结论:尼达尼布相关不良反应需引起临床高度警惕,要加强用药监测,在最大临床获益的同时将不良反应的危害降至最低。
Objective:To analyze regularities and characteristics of the adverse drug reactions(ADRs)associated with nintedanib and to provide reference for rational clinical drug use.Methods:ADR case reports of nintedanib were searched in databases including CNKI,VIP,Wanfang Data,Web of Science and Pubmed,from creation of the databases to October 2022 and analyzed statistically.Results:A total of 19 ADR cases were included,involving 21 patients.Most of ADRs were in elderly over 60 years old(n=17,80.95%)and primarily occurred within 30 days after medication(n=8,38.10%).Organs/systems involved in ADRs mainly focused in gastrointestinal disorders(n=6,28.57%).Three patients recovered after drug withdrawal,9 patients and 4 patients recovered after drug discontinuation combined with symptomatic treatment or surgical treatment,respectively,and 4 patients and 1 patient recovered after symptomatic treatment or surgical treatment without drug cessation,respectively.Conclusion:ADRs induced by nintedanib should be aroused high vigilance and closely monitored so as to minimize the risk of ADRs while maximizing clinical benefit.
作者
陈喆
秦艳
叶岩荣
CHEN Zhe;QIN Yan;YE Yan-rong(Department of Pharmacy,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2024年第3期307-312,共6页
Chinese Journal of New Drugs
关键词
尼达尼布
药物不良反应
文献分析
nintedanib
adverse drug reactions
literature analysis
