摘要
目的:分析吸入型糖皮质激素治疗慢性阻塞性肺疾病(COPD)的效果。方法:选择2021年6月—2023年5月广州市花都区花东镇中心卫生院内科收治的COPD患者148例作为研究对象,随机分为对照组和试验组,各74例。对照组给予沙丁胺醇治疗,试验组在对照组基础上给予糖皮质激素布地奈德治疗。比较两组治疗效果。结果:试验组患者康复总有效率高于对照组,差异有统计学意义(P=0.007)。试验组患者咳嗽、咳痰、呼吸困难的缓解时间短于对照组,差异有统计学意义(P<0.001)。治疗前,两组生活质量、舒适度评分比较,差异无统计学意义(P>0.05);治疗后,试验组生活质量、舒适度评分高于对照组,差异有统计学意义(P<0.001)。患者在治疗期间均未发生严重皮肤瘙痒、恶心、皮疹、头痛等不良反应。结论:吸入型糖皮质激素能显著提高COPD患者的康复有效率和生活质量,缩短症状缓解时间,同时具有良好的安全性,疗效确切。
Objective:To analyze the effect of inhaled glucocorticoids in the treatment of chronic obstructive pulmonary disease(COPD).Methods:One hundred and forty-eight COPD patients admitted to the Department of Internal Medicine of Guangzhou Huadong District Huadong Town Center Health Hospital from June 2021 to May 2023 were selected as the study subjects,and were randomly divided into the control group and the experimental group,seventy-four cases each.The control group was given salbutamol treatment,and the experimental group was given glucocorticoid budesonide treatment on the basis of the control group.Compare the treatment effect of the two groups.Results:The total effective rate of recovery of patients in the experimental group was higher than that of the control group,and the difference was statistically significant(P=0.007);The relief time of cough,spu⁃tum and dyspnea of patients in the experimental group was shorter than that of the control group,and the difference was statistical⁃ly significant(P<0.001);Before treatment,there was no statistically significant difference between the quality of life and comfort scores of the two groups(P>0.05);After treatment,the quality of life and comfort scores of the experimental group were higher than those of the control group,and the difference was statistically significant(P<0.001);None of the patients experienced adverse reactions such as severe skin itching,nausea,rash and headache during the treatment period.Conclusion:Inhaled glucocorticoids can significantly improve the recovery efficiency and quality of life of COPD patients,shorten the time of symptomatic relief,and at the same time have a good safety and efficacy.
作者
徐绮娜
Xu Qina(Department of Internal Medicine,Guangzhou Huadong District Huadong Town Center Health Hospital,Guangzhou 510890,Guangdong Province,China)
出处
《中外医药研究》
2023年第31期76-78,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
雾化吸入
糖皮质激素
布地奈德
慢性阻塞性肺疾病
Nebulized inhalation
Glucocorticoid
Budesonide
Chronic obstructive pulmonary disease
