摘要
目的探讨妊娠期糖尿病(GDM)患者脂联素(ADIPOQ)基因多态性与产后发生2型糖尿病(T2DM)的关系。方法回顾性选择2020年6月至2021年6月济宁医学院附属医院收治待产的236例GDM产妇作为观察对象,根据产后是否发生T2DM,分为T2DM组和无T2DM组,对比两组临床资料。采用双脱氧末端终止法检测ADIPOQ基因单核苷酸多态性(SNP)位点,并对rs17366568、rs822395、rs1501299、rs2241766这四个位点进行分型,通过logistic回归模型分析ADIPOQ基因型多态性和产后发生T2DM的关系。结果ADIPOQ基因rs2241766位点的携带G等位基因与T2DM发生呈负相关(OR=0.71、0.68,P<0.05)。rs2241766位点GT+GG基因型与TT基因型T2DM患者相比孕次≥2、HbA1c>8.5%发生风险降低,同样孕前BMI>25 kg/m^(2) T2DM患者更多为rs2241766 TT基因型携带者(P=0.026)。rs1501299位点携带T等位基因的(GT+TT)基因型为T2DM患者孕次、HbA1c的保护因素。结论ADIPOQ基因rs2241766和rs1501299多态性与GDM产妇产后T2DM易感性相关,rs2241766和rs1501299突变基因型的个体属T2DM高危人群。
Objective To investigate the relationship between adiponectin(ADIPOQ)gene polymorphism and postpartum type 2 diabetes mellitus(T2DM)in pregnant women with gestational diabetes mellitus(GDM).Methods A retrospective study was conducted on 236 GDM postpartum women admitted to the Affiliated Hospital of Jining Medical College from June 2020 to June 2021 as observation subjects.They were divided into a T2DM group and a non T2DM group based on the occurrence of T2DM after delivery.The clinical data of the two groups were compared.The double deoxygenation end termination method was used to detect the single nucleotide polymorphism(SNP)of the ADIPOQ gene,and the four loci rs17366568,rs822395,rs1501299,and rs2241766 were classified.The relationship between ADIPOQ genotype polymorphism and postpartum T2DM was analyzed using a logistic regression model.Results The G allele carrying the rs2241766 locus in ADIPOQ gene was negatively correlated with the occurrence of T2DM(OR=0.71,0.68,P<0.05).Compared with T2DM patients with TT genotype,the GT+GG genotype at the rs2241766 locus had a lower risk of occurrence for gestational age≥2 and HbA1c>85%.Similarly,T2DM patients with pre pregnancy body mass index(BMI)>25 kg/m^(2) were more likely to be carriers of the rs2241766 TT genotype(P=0.026).The(GT+TT)genotype carrying the T allele at the rs1501299 locus was a protective factor for gestational age and HbA1c in T2DM patients.Conclusions The rs2241766 and rs1501299 polymorphisms of the ADIPOQ gene are associated with susceptibility to postpartum T2DM in GDM women.Individuals with rs2241766 and rs1501299 mutant genotypes belong to the high-risk population for T2DM.
作者
吕祥花
柴云
仙娜
张亚南
冯雅琦
许丹妮
姜华梅
Lyu Xianghua;Chai Yun;Xian Na;Zhang Yanan;Feng Yaqi;Xu Danni;Jiang Huamei(Department of Obstetrics,Affiliated Hospital of Jining Medical College,Jining,Shandong 272100,China)
出处
《中国医师杂志》
CAS
2024年第2期191-195,共5页
Journal of Chinese Physician
基金
济宁市重点研发计划(2021YXNS114)。
关键词
糖尿病
妊娠
脂联素
多态性
单核苷酸
糖尿病
2型
Diabetes,gestational
Adiponectin
Polymorphism,single nucleotide
Diabetes mellitus,type 2
