摘要
目的:研究静脉滴注加雾化吸入盐酸氨溴索在新生儿呼吸窘迫综合征治疗中的临床效果。方法:选取2021年1月—2023年1月就诊的80例新生儿呼吸窘迫综合征患儿作为研究对象,按随机数字表法分成两组,各40例。两组均应用盐酸氨溴索治疗,对照组经雾化吸入给药,研究组经雾化吸入加静脉滴注给药,比较两组治疗总有效率、不良反应发生率、血清炎性因子、肺通气功能、动脉血气状况。结果:研究组总有效率高于对照组(P<0.05);研究组与对照组不良反应总发生率比较,差异无统计学意义(P>0.05);观察组标CRP、PCT、TNF-α水平低于对照组(P<0.05);观察组FEV1、FEV1/FVC、PaO_(2)高于对照组,PaCO_(2)低于对照组(P<0.05)。结论:盐酸氨溴索经由雾化吸入、静脉滴注两种途径联合用药可显著改善新生儿呼吸窘迫综合征炎症反应、肺功能、动脉血气状况,且不会增加不良反应,安全性良好。
Objective:To study the clinical effect of intravenous drip and atomization inhalation of ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome.Methods:A total of 80 children with neonatal respiratory distress syndrome who were admitted from January 2021 to January 2023 were selected as the research objects and divided into two groups according to the random number table method,with 40 children in each group.Both groups were treated with ambroxol hydrochloride.The control group was treated with atomization inhalation,and the study group was treated with atomization inhalation and intravenous drip.The total effective rate,incidence of adverse reactions,serum inflammatory factors,pulmonary ventilation function and arterial blood gas status were compared between the two groups.Results:The total effective rate of the study group was higher than that of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the study group and the control group(P>0.05).The levels of CRP,PCT and TNF-αin the observation group were lower than those in the control group(P<0.05).FEV1,FEV1/FVC and PaO_(2) in the observation group were higher than those in the control group,while PaCO_(2) was lower than that in the control group(P<0.05).Conclusion:Ambroxol hydrochloride combined with inhalation and intravenous drip could significantly improve the inflammatory response,lung function and arterial blood gas status of neonatal respiratory distress syndrome,without increasing adverse reactions,with good safety.
作者
马树峰
冯敏
MA Shufeng;FENG Min(Department of Pediatric Critical Care Medicine,Puyang People’s Hospital,Puyang 457000,Henan,China)
出处
《中国药物滥用防治杂志》
CAS
2024年第1期134-137,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
新生儿
呼吸窘迫综合征
盐酸氨溴索
雾化吸入
静脉滴注
Newborn
Respiratory distress syndrome
Ambroxol hydrochloride
Atomization inhalation
Intravenous infusion
