摘要
目的 探讨表皮生长因子联合湿润烧伤膏促进Wagner 1~2级糖尿病足创面愈合的疗效。方法 选取2020年1月至2022年12月于前海人寿广州总医院接受治疗的Wagner 1~2级糖尿病足52例患者为研究对象,随机分为单一烧伤膏组及联合生长因子组,各26例。单一烧伤膏组予以湿润烧伤膏,联合生长因子组在单一烧伤膏组基础上采用重组人表皮生长因子外用溶液治疗,比较两组患者创面愈合率及创面面积,基质金属蛋白酶9(MMP-9)、基质金属蛋白酶抑制剂-1(TIMP-1)水平,超氧化物歧化酶(SOD)、丙二醛(MDA)水平以及白细胞介素-6(IL-6)、血管细胞黏附分子1(VCAM-1)、碱性成纤维细胞生长因子2(FGF2)水平。结果 与单一烧伤膏组比较,联合生长因子组创面愈合率较高,且治疗7d后及治疗14d后创面面积均较小,差异有统计学意义(P<0.05);与单一烧伤膏组比较,治疗后联合生长因子组TIMP-1水平较高,MMP-9水平较低,差异有统计学意义(P<0.05);与单一烧伤膏组比较,治疗后联合生长因子组SOD水平较高,MDA水平较低,差异有统计学意义(P<0.05);治疗后联合生长因子组VCAM-1、FGF2及IL-6水平低于单一烧伤膏组,差异有统计学意义(P<0.05)。结论 在Wagner1~2级糖尿病足患者治疗中,以表皮生长因子联合湿润烧伤膏进行治疗,可促进创面愈合,维护机体的平衡,改善氧化应激指标,减轻炎症反应。
Objective To explore the curative effect of epidermal growth factor combined with MEBO in promoting wound healing of Wagner Grade 1~2 diabetic foot.Methods Fifty-two patients with Wagner Grade 1~2 diabetic foot who were treated in Guangzhou General Hospital of Foresea Life Insurance from January 2020 to December 2022 were selected as the study subjects and randomly divided into single burn cream group and combined growth factor group,with 26 patients in each group.The single burn cream group was treated with MEBO,and the combined growth factor group was treated with recombinant human epidermal growth factor external solution based on the single burn cream group.The wound healing rate,wound area,matrix metalloproteinase-9(MMP-9)and matrix metalloproteinase-1(TIMP-1),superoxide dismutase(SOD),malondialdehyde(MDA),interleukin-6(IL-6),vascular cell adhesion molecule 1(VCAM-1),basic fibroblast growth factor 2(FGF2)levels of the two groups were compared.Results Compared with the single burn cream group,the wound healing rate of combined growth factor group was higher,and the wound area was smaller after 7 days of treatment and 14 days of treatment,the difference was statistically significant(P<0.05).Compared with single burn cream group,TIMP-1 level was higher and MMP-9 level was lower in combined growth factor group after treatment,the difference was statistically significant(P<0.05).Compared with single burn cream group,SOD level was higher and MDA level was lower in combined growth factor group after treatment,and the difference was statistically significant(P<0.05).After treatment,the levels of VCAM-1,FGF2 and IL-6 in the combined growth factor group were lower than those in the single burn ointment group, and the differences were statistically significant (P<0.05). Conclusion In the treatment of Wagner Grade 1 to 2 diabetic foot patients, epidermal growth factor combined with MEBO can promote wound healing, maintain body balance, improve oxidative stress indexes, and reduce inflammation.
作者
张洋
王贤斌
周书敏
ZHANG Yang;WANG Xian-Bin;ZHOU Shu-Min(Department of Plastic Surgery,Guangzhou General Hospital of Foresea Life Insurance,Guangzhou 511300,China;Departmentof Endocrinology,Guangzhou Development Zone Hospital(Huangpu District People's Hospital),Guangzhou 510700,China)
出处
《中国药物经济学》
2023年第12期83-86,95,共5页
China Journal of Pharmaceutical Economics
