摘要
近些年,随着一些现代抗肿瘤药物的毒副作用日渐显露,天然植物药逐渐被大家熟知及重视,如紫杉、喜树果、长春花等,其中在植物荜茇中提取的荜茇酰胺,因其独特的药理活性,能广谱杀伤肿瘤细胞,而对正常细胞无明显毒性作用,逐渐获得众多研究学者的关注,但目前荜茇酰胺具体抗肿瘤机制尚未明确。通过以“荜茇酰胺”“活性氧(ROS)”“抗肿瘤”“Piperlongumine(PL)”“anti-tumour”“JNK”“miRNA”等为相关关键词,在万方数据库、中国知网、PubMed等数据库中查询近10年相关文献,对其抗肿瘤机制进行研究,为临床药物研发及其临床应用奠定基础。
In recent years,as the toxic and side effects of some modern anti-tumor drugs have increasingly emerged,natural plant medicine is gradually well-known and valued,Such as yew,taxus cuspidata,camptotheca acuminata decne,catharanthus roseus and so on.Among them,piperlongumine extracted from longum,due to its unique pharmacological activity,can kill tumor cells in a broad spectrum,but has no obvious toxic effects on normal cells,which has gradually attracted the attention of many researchers.However,the specific anti-tumor mechanism of piperlongumine has not yet been clarified.By using"Piperlongumine(PL)","reactive oxygen species(ROS)","anti-tumour","JNK","miRNA"as the key word,query relevant literatures in Wanfang database,CNKI,PubMed and other databases in recent 10 years to review its anti-tumor mechanism,laying a foundation for clinical drug research and development and clinical application.
作者
陈建海
李惠斌
CHEN Jianhai;LI Huibin(Weifang Medical University,Shandong Weifang 261000,China;Linyi People's Hospital,Shandong Linyi 276000,China)
出处
《现代肿瘤医学》
CAS
2024年第3期583-588,共6页
Journal of Modern Oncology
基金
山东省自然科学基金面上项目(编号:ZR2021MH290)。
