摘要
目的 探讨腔隙性脑梗死(LI)合并脑微出血(CMBs)的危险因素及与脑白质病变(WML)的关系。方法 于2020年3月至2022年6月在海南省老年病医院收集LI患者134例,根据磁敏感加权成像(SWI)检测CMBs,分为CMBs组(49例)和非CMBs组(85例),利用脑白质病变量表评分(WMLs)分析LI患者脑白质病情情况与CMBs相关性,采用Logistic回归模型分析LI患者并发CMBs的危险因素。结果 134例LI患者合并CMBs发生率为36.57%(49/134例)。CMBs组WML发生率、WMLs评分明显高于非CMBs组(P<0.05);多因素Logistic回归分析显示,血尿酸、高血压史、高密度脂蛋白(HDL)、WML发生率和WMLs评分是LI患者发生CMBs的独立影响因素。且CMBs病灶数量与WMLs评分存在明显正相关(r=0.412,P<0.05)。结论 LI患者发生CMBs发生影响因素众多,控制血压、血脂水平以及降低血尿酸对于预防LI患者发生CMBs具有重要意义,且脑白质病变程度与CMBs严重程度紧密相关。
Objective To explore the risk factors of lacunar infarction(LI) complicated with cerebral microhemorrhage(CMBs) and the relationship between them and white matter lesions(WML).Methods From March2020 to June 2022,134 patients with LI were prospectively collected in hainan geriatrics hospital.According to magnetic sensitivity weighted imaging(SWI),CMBs were detected,and divided into CMBs group(49 cases) and non-CMBs group(85 cases).The relationship between the situation of leukoencephalopathy and CMBs in LI patients was analyzed by white matter lesion scale(WMLs),and the risk factors of complicated with CMBs in LI patients were analyzed by Logistic regression model.Results The incidence of CMBs in 134 LI patients was 36.57%(49/134).The incidence of WML and WMLs score in CMBs group were significantly higher than those in non-CMBs group(P <0.05);Multivariate Logistic regression analysis showed that serum uric acid,history of hypertension,high-density lipoprotein(HDL),WML incidence and WMLs score were independent influencing factors for the occurrence of CMBs in LI patients.The number of CMBs lesions was significantly positively correlated with WMLs score(r=0.412,P <0.05).Conclusion There are many factors affecting the occurrence of CMBs in LI patients.Controlling blood pressure,blood lipid level and reducing serum uric acid are of great significance in preventing the occurrence of CMBs in LI patients,and the degree of white matter lesions is closely related to the severity of CMBs.
作者
叶经香
龙淑媛
张应魏
卢方理
吴恳
Ye Jingxiang;Long Shuyuan;Zhang Yingwei;Lu Fangli;Wu Ken(Department of Neurology,Hainan Geriatrics Hospital,Haikou 571100,China)
出处
《脑与神经疾病杂志》
CAS
2024年第2期111-115,共5页
Journal of Brain and Nervous Diseases
基金
2020年度海南省卫生健康行业科研项目(20A200326)。
关键词
腔隙性脑梗死
脑微出血
影响因素
脑白质病变
Lacunar infarction
Cerebral microhemorrhage
Influencing factors
White matter lesions
