摘要
细胞间黏附分子1(ICAM-1)是能介导白细胞和内皮细胞黏附的主要蛋白质分子之一,可以造成小血管病变。本文重点阐述脑小血管病可能发病机制及其与ICAM-1的关系,为进一步探讨ICAM-1与脑小血管病的关系提供依据,推测ICAM-1基因的多态性可能与脑小血管病的发生有相关性。
Intercellular adhesion molecule 1 (ICAM-1) is one of the main molecules that mediate the adhesion of leukocytes to endothelial cells,which can cause small vessel disease.The following focuses on the possible pathogenesis of cerebral small vessel disease and its relationship with ICAM-1,providing a basis for further investigation of the relationship between ICAM-1 and cerebral small vessel disease.It is speculated that the polymorphism of ICAM-1 gene may be related to the occurrence of cerebral small vessel disease.
作者
哈拉木江·赛力克
孔祥锋
HALA Mu Jiang·SaiLiKe;KONG Xiangfeng(Xinjiang Medical University,Urumqi 830011,China;Departmentof Neurology,the Fifth Affiliated Hospitalof Xinjiang Medical University,Urumqi 830011,China)
出处
《中国实用神经疾病杂志》
2019年第8期922-928,共7页
Chinese Journal of Practical Nervous Diseases
基金
新疆维吾尔自治区自然科学基金资助项目(编号:2015211C164)
关键词
细胞间黏附分子-1
血脑屏障
脑小血管病
腔隙性梗死
脑白质疏松
脑微出血
血管周围间隙扩大
脑萎缩
基因多态性
ICAM-1
Blood brain barrier
Cerebral small vessel disease
Lacunar infarction
White matter Leukoaraiosis
cerebral microbleed
Enlarged perivascular spaces
Cerebral atrophy
Genetic polymorphism
