摘要
目的分析炎症、营养指标与慢性阻塞性肺疾病急性加重期(AECOPD)患者合并低蛋白血症的相关性。方法回顾性分析2020年1月至2022年9月在厦门大学附属第一医院呼吸与危重症医学科收治的AECOPD患者的病例资料,根据血清白蛋白(ALB)是否低于35 g/L分为低蛋白血症组(n=73)与非低蛋白血症组(n=141)。比较两组临床资料、炎症指标和营养指标,Spearman进行相关性分析,二元logistic回归分析AECOPD患者合并低蛋白血症的影响因素。结果两组患者年龄、住院时间、体重比较差异均有统计学意义(P<0.05);而性别、过去1年内住院次数、身高,以及合并糖尿病、高血压、冠心病比例比较差异均无统计学意义(P>0.05)。与非低蛋白血症组比较,低蛋白血症组的住院时间更长,C反应蛋白、中性粒细胞与白蛋白比值(NAR)、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)和全身免疫炎症指数(SII)水平更高,预后营养指数(PNI)、体重指数(BMI)、血红蛋白、总蛋白水平更低,差异有统计学意义(P<0.05)。体重、BMI、血红蛋白、总蛋白、PNI与AECOPD患者合并低蛋白血症呈负相关(P<0.05),而年龄、住院时间、C反应蛋白、NAR、NLR、PLR、SII与AECOPD患者合并低蛋白血症呈正相关(P<0.05)。二元logistic回归分析显示,PNI、SII、NLR是AECOPD患者合并低蛋白血症的影响因素。结论在临床上应重视并及时纠正AECOPD患者的低蛋白血症状态,改善患者炎症指标和营养状况,预防急性加重。
Objective To analyze the correlation between inflammation,nutritional indicators and hypoproteinemia in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods The clinical data of patients with AECOPD admitted to the Department of Respiratory and Critical Care Medicine of the First Affiliated Hospital of Xiamen University from January 2020 to September 2022 were retrospectively analyzed,and the patients were divided into the hypoproteinemia group(n=73)and the non-hypoproteinemia group(n=141)according to whether the serum albumin(ALB)was lower than 35 g/L.The clinical data,inflammatory indicators and nutritional indicators of the two groups were compared,Spearman correlation analysis was performed,and binary logistic regression analysis was performed to analyze the influencing factors of patients with AECOPD complicated with hypoproteinemia.Results There were statistically significant differences in age,length of hospital stay,and body weight between the two groups(P<0.05).There were no significant differences in gender,number of hospitalizations in the past 1 year,height,diabetes,hypertension and proportion of coronary heart disease(P>0.05).Compared with the non-hypoproteinemia group,the hypoproteinemia group had longer hospital stays and higher levels of C-reactive protein,neutrophil/albumin ratio(NAR),neutrophil to lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR),and systemic immunoinflammatory index(SII).The prognostic nutritional index(PNI),body mass index(BMI),hemoglobin and total protein levels were lower,and the difference was statistically significant(P<0.05).Body weight,BMI,hemoglobin,total protein,PNI and AECOPD patients with hypoproteinemia were negatively correlated(P<0.05),while age,length of hospital stay,C-reactive protein,NAR,NLR,PLR,SII and AECOPD patients with hypoproteinemia were positively correlated(P<0.05).Binary logistic regression analysis showed that PNI,SII and NLR were the influencing factors of hypoproteinemia in AECOPD patients.Conclusion In clin
作者
李凤
刘海月
林益华
王佳怡
杨菀臻
郑怡萱
甘仲霖
LI Feng;LIU Haiyue;LIN Yihua;WANG Jiayi;YANG Wanzhen;ZHENG Yixuan;GAN Zhonglin(School of Public Health,Southwest Medical University,Luzhou,Sichuan 646099,China;Department of Clinical Laboratory,The First Affiliated Hospital of Xiamen University,Xiamen,Fujian 361000,China;Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Xiamen University,Xiamen,Fujian 361000,China;School of Public Health,Xiamen University,Xiamen,Fujian 361000,China)
出处
《重庆医学》
CAS
2024年第4期517-521,共5页
Chongqing medicine
基金
国家自然科学基金青年项目(82202629)
福建省卫生健康科技计划项目(2021QN0101)
2023年福建省厦门市医疗卫生重点项目(3502Z20234010)。
关键词
慢性阻塞性肺疾病急性加重期
低蛋白血症
炎症
营养
acute exacerbation of chronic obstructive pulmonary disease
hypoproteinemia
inflammation
nutrition
