摘要
目的 探讨涤痰汤加减联合电针治疗难治性精神分裂症的疗效及认知功能、血清学指标变化情况。方法 选取2019年7月-2021年7月衡水市第七人民医院精神科收治的150例难治性精神分裂症为研究对象,按随机数字表法将其分为对照组和试验组,各75例。对照组给予氯氮平片进行治疗,试验组在对照组基础上给予涤痰汤加减联合电针治疗,2组均治疗8周。比较2组治疗8周后的临床疗效,治疗前后中医症候积分、精神症状、认知功能、脂代谢指标、血清学指标水平及治疗期间的安全性。结果 与对照组治疗8周后的总有效率(78.67%)比较,试验组总有效率(93.33%)更高(P <0.05)。治疗8周后,2组神志呆钝、胸闷肋痛、喜静恶动、忧虑多疑、阳性和阴性症状量表(PANSS)、简明精神病量表(BPRS)评分及血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平与治疗前比较均降低,试验组低于对照组(P <0.05);2组韦氏成人记忆量表(WMS-RC)评分及血清高密度脂蛋白胆固醇(HDL-C)、脑源性神经营养因子(BDNF)、5-羟色胺(5-HT)、促甲状腺激素(TSH)、褪黑素(MT)水平与治疗前比较均升高,试验组高于对照组(P <0.05)。与对照组治疗期间的不良反应总发生率(16.00%)比较,试验组不良反应总发生率(5.33%)更低(P <0.05)。结论 涤痰汤加减联合电针可明显调节难治性精神分裂症患者脂代谢及血清学指标水平,改善患者中医症候、精神症状及认知功能,进而可提高临床疗效,且具有较好的安全性。
Objective To explore the effect of modified Ditan decoction combined with electroacupuncture in the treatment of refractory schizophrenia and the changes of cognitive function and serological indexes.Methods 150 patients with refractory schizophrenia admitted to the Department of Psychiatry of Hengshui Seventh People's Hospital from July 2019 to July 2021 were selected and divided into the control group(75 cases)and the experiment group(75 cases)according to random number table method.The control group was treated with clozapine tablets,and the experiment group was treated with modified Ditan decoction combined with electroacupuncture on the basis of the treatment of the control group.Both groups were treated for 8 weeks.The curative effect after 8 weeks of treatment,traditional Chinese medicine symptom scores,mental symptoms,cognitive function,levels of lipid metabolism indexes and serological indexes before and after treatment,and the safety during treatment of two groups were compared.Results Compared with the total effective rate of the control group after 8 weeks of treatment(78.67%),the total effective rate of the experiment group was higher(93.33%,P<0.05).After 8 weeks of treatment,the scores of dullness of mind,chest tightness and costalgia,restlessness and dysphoria,anxiety and suspicion,positive and negative symptoms scale(PANSS)and brief psychiatric scale(BPRS),and the levels of serum total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)in two groups were lower than those before treatment,and the experiment group was lower than the control group(P<0.05);Compared with berore treatment,the scores of Wechsler adult memory scale(WMS-RC),and the levels of serum high-density lipoprotein cholesterol(HDL-C),brain-derived neurotrophic factor(BDNF),5-hydroxytryptamine(5-HT),thyroid stimulating hormone(TSH)and melatonin(MT)in two groups increased,and the experiment group was higher than the control group(P<0.05).Compared with the total incidence of adverse reactions during treatment in the control g
作者
刘医农
谢春平
焦英霞
LIU Yinong;XIE Chunping;JIAO Yingxia(Department of Psychiatry,Hengshui Seventh People's Hospital,Hengshui 053000,China)
出处
《长春中医药大学学报》
2024年第1期65-69,共5页
Journal of Changchun University of Chinese Medicine
基金
河北省中医药管理局科研计划(2023465)。
关键词
难治性精神分裂症
涤痰汤
电针
脂代谢
血清学
中医症候
认知功能
安全性
refractory schizophrenia Ditan decoction
electroacupuncture
lipid metabolism
serology
traditional Chinese medicine symptom
cognitive function
safety
