摘要
探讨癫狂梦醒汤加减联合阿立哌唑治疗精神分裂症肝郁痰结证的疗效以及对血脂代谢和超敏C反应蛋白的影响。方法选取2018年6月—2019年6月医院收治精神分裂症患者72例,按随机数字表法分为对照组和观察组各36例。对照组单用阿立哌唑片治疗8周。观察组给予癫狂梦醒汤加减联合阿立哌唑片治疗。治疗8周后,比较两组住院精神患者社会功能评定(SSPI)量表、临床总体印象疗效总评量表病情严重程度(CGI-SI)、阳性与阴性症状量表(PANSS)评分、临床疗效以及血脂代谢、超敏C反应蛋白水平。结果观察组总有效率显著高于对照组[83.33%(30/39)vs 58.33%(21/36),P=0.038]。与治疗前比较,两组治疗后SSPI量表评分显著升高,CGI-SI、PANSS评分明显降低,且观察组改善较对照组明显(P<0.01)。与治疗前比较,观察组治疗后的高脂血症(TG)、总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)明显下降,高密度脂蛋白胆固醇(HDL-C)显著升高,且改善较对照组明显(P<0.01);对照组治疗前后以上指标改善差异均无统计学意义(P>0.05)。与治疗前比较,两组治疗后超敏C反应蛋白明显下降,且观察组改善较对照组明显(P<0.01)。结论癫狂梦醒汤加减联合阿立哌唑治疗精神分裂症肝郁痰结证的疗效显著,能够改善患者的症状,且有利于患者血脂代谢的好转及抑制炎症反应。
Objective To investigate the efficacy of Diankuang Mengxing Decoction(癫狂梦醒汤)combined with aripiprazole on treating schizophrenia with syndrome of liver depression and phlegm and its effect on blood lipid metabolism and hypersensitive c-reactive protein.Method Seventy-two schizophrenia admitted to our hospital from June 2018 to June 2019 were selected and divided into control group and observation group with 36 cases in each according to the random number table method.The control group was treated with aripiprazole alone for 8 weeks.The observation group was given Diankuang Mengxing Decoction combined with aripiprazole.After 8 weeks’treatment,scores of evaluation of social function of inpatients with mental illness(SSPI),the severity of clinical general impression rating scale(CGI-SI),positive and negative symptom scale(PANSS),the clinical efficacy,lipid metabolism and hypersensitive c-reactive protein levels were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group[83.33%(30/36)vs 58.33%(21/36),P=0.038].Compared with those before treatment,SSPI scale scores of the two groups were significantly increased after treatment and scores of CGI-SI and PANSS were significantly decreased and the improvement of the observation group was significantly higher than that of the control group(P<0.01).Compared with those before treatment,hyperlipidemia(TG),total cholesterol(TC)and low-density lipoprotein-cholesterol(LDL-C)in the observation group were significantly decreased after treatment,while high-density lipoprotein cholesterol(HDL-C)significantly increased,and the improvement was more obvious than that in the control group(P<0.01),and there was no statistically significant difference in the improvement of the above indicators before and after treatment in the control group(P>0.05).Compared with those before treatment,the hypersensitive C-reactive protein of the two groups was decreased significantly after treatment,and t
作者
潘秀娟
尹晓莉
李康宁
PAN Xiujuan;YIN Xiaoli;LI Kangning(Wenzhou Kangning Hospital,Wenzhou 325007,Zhejiang,China)
出处
《中华中医药学刊》
CAS
北大核心
2021年第12期175-178,共4页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省医院可持续发展正大天晴研究项目(2018ZHA-ZDTQ2017)。
关键词
精神分裂症
癫狂梦醒汤
肝郁痰结证
血脂代谢
超敏C反应蛋白
schizophrenia
Diankuang Mengxing Decoction(癫狂梦醒汤)
syndrome of liver depression and phlegm
blood lipid metabolism
hypersensitive C-reactive protein
