摘要
目的探讨患者胸腔镜肺癌根治术后肺部感染易感因素及微小核糖核酸(miR)-31、miR-122、miR-146a表达水平变化。方法选取171例2018年01月-2022年12月于简阳市人民医院行胸腔镜肺癌根治术患者为研究对象,根据患者术后是否发生肺部感染分为感染组34例和非感染组137例,分析肺部感染患者病原学特点、易感因素及外周血miR-31、miR-122、miR-146a表达水平。结果171例患者胸腔镜肺癌根治术后肺部感染为34例,发生率为19.88%;共培养出病原菌35株,其中革兰阴性菌27株,占77.14%;易感因素包括年龄>60岁、有吸烟史及糖尿病(P<0.05);与非感染组相比,感染组患者外周血miR-31、miR-122水平升高,miR-146a水平降低(P<0.05),三指标联合诊断胸腔镜肺癌根治术后肺部感染的曲线下面积(AUC)值为0.946,敏感度、特异度分别为91.18%、87.59%。结论胸腔镜肺癌根治术患者肺部感染发生率较高,病原菌以革兰阴性菌为主,易感因素包括年龄>60岁、有吸烟史、有糖尿病,miR-31、miR-122、miR-146a三者联合检测可提高对该病的诊断价值,临床可进行针对性防治以降低该病发生风险。
OBJECTIVE To explore the predisposing factors for postoperative pulmonary infection in the lung cancer patients undergoing thoracoscopic radical resection and analyze the changes of relative expression levels of micro ri-bonucleic acid(miR-31),miR-122 and miR-146a.METHODS Totally 171 lung cancer patients who underwent the thoracoscopic radical resection in the People's Hospital of Jianyang City from Jan 2018 to Dec 2022 were recruited as the research subjects and were divided into the infection group with 34 cases and the non-infection group with 137 cases according to the status of postoperative pulmonary infection.The etiological characteristics,predispo-sing factors for the pulmonary infection and expression levels of peripheral blood miR-31,miR-122 and miR-146a were observed.RESULTS Among the 171 lung cancer patients who underwent the thoracoscopic radical resection,34 had postoperative pulmonary infection,with the incidence rate 19.88%.Totally 35 strains of pathogens were i-solated,27(77.14%)of which were gram-negative bacteria.The predisposing factors included more than 60 years of age,smoking history and diabetes mellitus(P<0.05).The expression levels of peripheral blood miR-31 and miR-122 of the infection group were higher than those of the non-infection group,while the expression level of miR-146a of the infection group was lower than that of the non-infection group(P<0.05).The area under curve(AUC)of the joint detection of the three indexes was 0.946 in diagnosis of the postoperative pulmonary infection,with the sensitivity 91.18%,the specificity 87.59%.CONCLUSION The incidence of pulmonary infection is high among the lung cancer patients undergoing thoracoscopic radical resection.The gram-negative bacteria are dominant among the pathogens.The predisposing factors include the more than 60 years of age,smoking his-tory and diabetes mellitus.The joint detection of miR-31,miR-122 and miR-146a may raise the diagnostic value.It is necessary for the hospital to take targeted prevention and treatment measures
作者
马伟
王世平
王代平
陈涛
蒲江涛
MA Wei;WANG Shi-ping;WANG Dai-ping;CHEN Tao;PU Jiang-tao(Af filiated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China;不详)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2024年第1期50-54,共5页
Chinese Journal of Nosocomiology
基金
四川省自然科学基金(2021KJ0340)。
