摘要
目的:探讨低分子肝素钙联合来曲唑治疗多囊卵巢综合征(PCOS)不孕症疗效及对血浆D-二聚体(D-D)、纤维蛋白肽A(FPA)的影响。方法:将2020年10月-2022年10月本院就诊的90例PCOS不孕症患者随机分两组,均给予来曲唑治疗,联合组联合低分子肝素钙治疗,比较两组疗效及血浆D-二聚体(D-D)、纤维蛋白肽A(FPA)水平变化。结果:联合组总有效率(93.3%)高于常规组(77.8%),治疗后3、12个月后排卵率及妊娠率均高于常规组,子宫动脉阻力指数(0.62±0.07)、搏动指数(1.54±0.26)低于常规组(0.75±0.08、1.91±0.32),子宫内膜厚度(9.92±1.58 mm)高于常规组(8.76±1.44mm),血浆D-D(0.32±0.09mg/L)、FPA(8.52±2.39mg/L)低于常规组(3.56±0.48 mg/L、11.71±3.30mg/L)(P<0.05),两组不良反应(17.8%、11.1%)无差异(P>0.05)。结论:低分子肝素钙与来曲唑联合治疗PCOS不孕症疗效提高,可促进患者排卵及妊娠,改善血浆D-D、FPA水平,且安全性良好。
Objective:To explore the therapeutic effect of low molecular weight heparin calcium combined with letrozole for treating patients with infertilty because of polycystic ovary syndrome(PCOS),and to study its impacts on the lev-els of plasma D-dimer(D-D)and fibrinopeptide A(FPA)of the patients.Methods:90 patients with infertility because of PCOS were randomly divided into study group and control group from October 2020 to October 2022.The patients in the two groups received treatment with letrozole,while the patients in the study group received treatment of low molecular weight heparin calcium additionally.The therapeutic effect and the changes of the plasma D-D and FPA levels of the patients were compared between the two groups.Results:The total effective rate(93.3%)of the patients in the study group was significantly higher than that(77.8%)of the patients in the control group.The ovulation rate and the pregnancy rate of the patients in the study group after 3 and 12 months of treatment were significantly higher than those of the patients in the control group.The uterine artery resistance index(0.62±0.07)and the pulsatility index(1.54±0.26)of the patients in the study group were significantly lower than those(0.75±0.08 and 1.91±0.32)of the patients in the control group.The endometrial thickness(9.92±1.58 mm)of the patients in the study group was sig-nificantly higher than that(8.76±1.44 mm)of the patients in the control group.The levels of plasma D-D(0.32±0.09 mg/L)and FPA(8.52±2.39 mg/L)of the patients in the study group were significantly lower than those(3.56±0.48 mg/L and 11.71±3.30 mg/L)of the patients in the control group(P<0.05).There was no significant difference in the adverse reactions rate(17.8%vs 11.1%)of the patients between the two groups(P>0.05).Conclusion:Low molecular weight heparin calcium combined with letrozole for treating the patients with infertility because of PCOS has higher therapeutic effect,which can promote the ovulation and pregnancy and improve the plasma D-D and FPA levels
作者
何末琴
陆金
HE Moqin;LU Jin(Changxing Maternal and Child Health Care Hospital,Huzhou,Zhejiang Province,313100)
出处
《中国计划生育学杂志》
2024年第2期365-368,373,共5页
Chinese Journal of Family Planning
基金
湖州市科技局项目(2018GY68)。
