摘要
目的分析维生素D受体基因(vitamin D receptor,VDR)启动子FokⅠ多态性和原发性肾结石发病率的关联性,以期为临床早期干预提供可参考依据。方法选取郑州市第七人民医院2022年1月至2023年4月期间接收的原发性肾结石患者200例作为病例组,另选取健康体检人群中非泌尿系结石志愿者200例作为对照组,统计对比两组一般资料、VDR FokⅠ基因型,对比不同VDR FokⅠ基因型患者尿指标,并分析不同VDR FokⅠ基因型患者发生原发性肾结石的危险度。结果病例组24 h尿磷酸盐排泄量、24 h尿钙排泄量均明显多于对照组(P<0.05);对照组VDR FokⅠ基因型主要构成为FF、Ff,病例组VDR FokⅠ基因型主要构成为Ef、ff,两组VDR FokⅠ基因型分布情况对比,差异具有统计学意义(P<0.05);病例组VDR FokⅠ等位基因中F频次明显低于对照组,f频次明显高于对照组(P<0.05);病例组不同VDR FokⅠ基因分型患者的24h尿磷酸盐排泄量、24h尿钙排泄量对比,均无明显差异(P>0.05);危险度分析显示,VDR FokⅠ基因分型中FF分型患者发生原发性肾结石危险度为Ff分型的0.944倍、ff分型的0.752倍,VDR FokⅠ基因分型中Ff分型患者发生原发性肾结石的危险度为ff分型的0.767倍。结论原发性肾结石患者的24 h尿磷酸盐排泄量以及24 h尿钙排泄量较高,且VDR FokⅠ基因分型中ff基因人群发生原发性肾结石的危险度高,需尽早进行预防措施干预,以降低发生率。
Objective To analyze the association between FokⅠpolymorphism of vitamin D receptor gene(VDR)promoter and primary kidney stone incidence in order to provide reference for early clinical intervention.Methods Totally 200 patients with primary kidney stones admitted in the 7th People's Hospital of Zhengzhou from January 2022 to April 2023 were selected as the case group,and 200 volunteers with non-urinary stones were selected as the control group.General data,VDR FokⅠgenotypes and urinary indexes of patients with different VDR FokⅠgenotypes were statistically compared between the two groups.The risk of primary kidney stones in patients with different VDR FokⅠgenotypes was analyzed.Results The 24 h urinary phosphate excretion and 24 h urinary calcium excretion in case group were significantly higher than those of control group(P<0.05).The VDR FokⅠgenotype in the control group was mainly composed of FF and Ff,while the VDR FokⅠgenotype in the case group was mainly composed of Ef and ff,and the difference of VDR FokⅠgenotype distribution between the two groups Was statistically significant(P<0.05).The frequency of F in VDR FokⅠallele in case group was significantly lower than that of control group,and the frequency of f was significantly higher than that of control group(P<0.05).There was no significant difference in 24 h urinary phosphate excretion and 24 h urinary calcium excretion among different VDR FokⅠgenotypes in case group(P>0.05).Risk analysis showed that the risk of primary kidney stones in FF type patients in VDR Fok I genotype was 0.944 times of Ff type patients and 0.752 times of ff type patients,and the risk of primary kidney stones in Ff type patients in VDR FokⅠgenotype was 0.767 times of ff type patients.Conclusion 24 hurinary phosphate excretion and 24 h urinary calcium excretion are higher in primary kidney stones,and the risk of primary kidney stones is higher in the FF gene population with VDR FokⅠgenotype.Early preventive intervention is needed to reduce the incidence.
作者
李中学
姜威宏
张涛
刘一鸿
LI Zhong-xue;JIANG Wei-hong;ZHANG Tao;LIU Yi-hong(Department of Urology,the 7th Peoples Hospital of Zhengzhou,Zhengzhou 450016,China)
出处
《医药论坛杂志》
2023年第23期33-36,42,共5页
Journal of Medical Forum
基金
河南省医学科技攻关计划联合共建项目(LHGJ20220845)。
